Selection of Plasmodium falciparum pfmdr1 Alleles following Therapy with Artemether-Lumefantrine in an Area of Uganda where Malaria Is Highly Endemic

Autor:	Grant Dorsey, Bryan Greenhouse, Christian Dokomajilar, Philip J. Rosenthal, Samuel L. Nsobya
Rok vydání:	2006
Předmět:	Artemether/lumefantrine Endemic Diseases Plasmodium falciparum Biology Pharmacology Lumefantrine Apicomplexa Antimalarials chemistry.chemical_compound Pharmacotherapy Mechanisms of Resistance parasitic diseases Prevalence medicine Animals Humans Uganda Pharmacology (medical) Artemether Malaria Falciparum Selection Genetic Allele Alleles Fluorenes Polymorphism Genetic Artemether Lumefantrine Drug Combination biology.organism_classification medicine.disease Virology Artemisinins Drug Combinations Infectious Diseases chemistry Ethanolamines Drug Therapy Combination Genes MDR Sesquiterpenes Malaria medicine.drug
Zdroj:	Antimicrobial Agents and Chemotherapy. 50:1893-1895
ISSN:	1098-6596 0066-4804
Popis:	Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8e18682e6ac96f1a72803e1604e6c1 https://doi.org/10.1128/aac.50.5.1893-1895.2006 Zobrazit plný text záznamu