Relevance of anti-Mullerian hormone measurement in a routine IVF program
| Autor: | Andreas N. Schüring, K. Friol, J. Tigges, Christian Gnoth, Erhard Godehardt, P. Mallmann |
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| Rok vydání: | 2008 |
| Předmět: |
Infertility
Adult Anti-Mullerian Hormone endocrine system medicine.medical_specialty endocrine system diseases Pregnancy Rate Oocyte Retrieval Controlled ovarian hyperstimulation Fertilization in Vitro Biology Sensitivity and Specificity Andrology Predictive Value of Tests Pregnancy medicine Humans Inhibins Prospective Studies Prospective cohort study Ovarian reserve Gynecology urogenital system Rehabilitation Ovary Age Factors Obstetrics and Gynecology Anti-Mullerian Hormone Measurement medicine.disease Antral follicle female genital diseases and pregnancy complications Pregnancy rate Reproductive Medicine Female Follicle Stimulating Hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Human reproduction (Oxford, England). 23(6) |
| ISSN: | 1460-2350 |
| Popis: | BACKGROUND: Diminished ovarian reserve has become a major cause of infertility. Anti-Mullerian hormone (AMH) seems to be a promising candidate to assess ovarian reserve and predict the response to controlled ovarian hyperstimulation (COH). This prospective study was conducted to evaluate the relevance of AMH in a routine IVF program. METHODS: Three hundred and sixteen patients were prospectively enrolled to enter their first IVF/ ICSI-cycle. Age, FSH-, inhibin B- and AMH-levels and their predictive values for ovarian response and clinical pregnancy rate were compared by discriminant analyses. RESULTS: A total of 132 oocyte retrievals were performed. A calculated cut-off level ≤1.26 ng/ml AMH alone detected poor responders (≤4 oocytes) with a sensitivity of 97%, and there was a 98% correct prediction of normal response in COH if levels were above this threshold. With levels |
| Databáze: | OpenAIRE |
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