Does cow's milk protein elimination diet have a role on induction and maintenance of remission in children with ulcerative colitis?
| Autor: | Massimo Martinelli, Eleonora Giannetti, Elisa Sciorio, Erasmo Miele, Annamaria Staiano, Caterina Strisciuglio |
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| Přispěvatelé: | Strisciuglio, Caterina, Giannetti, Eleonora, Martinelli, Massimo, Sciorio, Elisa, Staiano, Annamaria, Miele, Erasmo, Eleonora, Giannetti, Massimo, Martinelli, Elisa, Sciorio, Annamaria, Staiano, Erasmo, Miele |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Comorbidity Inflammatory bowel disease Gastroenterology law.invention chemistry.chemical_compound Randomized controlled trial Mesalazine law Internal medicine Elimination diet medicine Animals Humans Prospective Studies Colitis Prospective cohort study Child business.industry Remission Induction General Medicine medicine.disease Ulcerative colitis Milk chemistry Concomitant Child Preschool Pediatrics Perinatology and Child Health Immunology Colitis Ulcerative Female Milk Hypersensitivity business |
| Popis: | Aim Aims of this study were to evaluate the efficacy of a cow's milk protein (CMP) elimination diet on induction and maintenance of remission and to define association with atopy in children with ulcerative colitis (UC). Methods Twenty-nine consecutive patients (mean age: 11.2 years; range: 4.6–17 years; F/M: 15/14) with newly diagnosed UC were randomized either to receive a CMP elimination diet (n = 14) or to continue a free diet (n = 15) associated with concomitant steroid induction and mesalazine maintenance treatment. Children were prospectively evaluated at four time points: within 1 month, 6 months and 1 year after diagnosis or at the time of relapse. Results Twenty-five of the 29 enrolled patients responded to the UC induction therapy with a complete remission (86.2%), 13 belonging to CMP elimination diet group and 12 to free diet group (p = 0.59). Overall, our data showed that 7 of 13 (53.8%) patients treated with CMP elimination diet and 8 of 15 (53.3%) patients on free diet and UC therapy relapsed within 1 year of follow-up (p = 1). Conclusions In conclusion, data of this paediatric, randomized trial suggest that CMP elimination has no role in the management of UC in non-sensitized children. |
| Databáze: | OpenAIRE |
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