Expression of insulin-like growth factor-I and -II genes in rat medullary thyroid carcinoma
| Autor: | R. J. C. Slebos, Cornelis J.M. Lips, B. A. Roos, John S. Sussenbach, Jwm Hoppener, Marnix Jansen, J.L. Van den Brande, P.H. Steenbergh, H.S. Jansz, P. de Pagter-Holthuizen |
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| Jazyk: | angličtina |
| Předmět: |
medicine.medical_specialty
Cellular differentiation medicine.medical_treatment Biophysics Tumor differentiation Biology Biochemistry Thyroid carcinoma insulin-like growth factor Insulin-like growth factor Insulin-Like Growth Factor II Somatomedins Structural Biology rat medullary thyroid carcinoma Internal medicine Gene expression Genetics medicine RNA Messenger RNA Neoplasm Thyroid Neoplasms Insulin-Like Growth Factor I Autocrine signalling Molecular Biology (Rat medullary thyroid carcinoma) northern blotting Growth factor Carcinoma RNA DNA Cell Biology Endocrinology Gene Expression Regulation tumor differentiation Cancer cell Cancer research gene expression Northern blotting Poly A Biologie |
| Zdroj: | FEBS Letters, 215(1), 122. Elsevier |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(87)80125-4 |
| Popis: | Several types of cancer cells produce polypeptide growth factors and often the same cells have functional receptors for the released growth factor (autocrine secretion). We have studied expression of genes encoding somatomedin-C/insulin-like growth factor-I (Sm-C/IGF-I) and IGF-II, in rat medullary thyroid carcinomas (MTCs) in different stages of tumour differentiation. RNAs hybridizing specifically to an IGF-I cDNA probe were detected in 6 out of 7 differentiated MTCs and IGF-II related RNAs were demonstrated in 5 out of these 7 differentiated MTCs. In 5 anaplastic MTCs no IGF RNAs were detected, except for a small amount of IGF-II related RNA in one tumour. |
| Databáze: | OpenAIRE |
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