Long-Term Survival with ACTH-Secreting Carcinoma of the Pituitary: A Case Report and Review of the Literature
| Autor: | Sharon L. Wardlaw, Rita E. Landman, R E Peterson, Alexander G. Khandji, Melvin Horwith |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Pituitary gland Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry Adrenocorticotropic hormone Biochemistry Cushing syndrome Endocrinology Adrenocorticotropic Hormone Pituitary adenoma Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Pituitary Neoplasms Radiotherapy business.industry Biochemistry (medical) Middle Aged medicine.disease Combined Modality Therapy Magnetic Resonance Imaging Survival Analysis Surgery Radiation therapy Sella turcica medicine.anatomical_structure Pituitary carcinoma Female Tomography X-Ray Computed business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 87:3084-3089 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.87.7.8667 |
| Popis: | A 48-yr-old woman was evaluated 21 yr after receiving treatment for an ACTH-secreting metastatic pituitary carcinoma. She had been diagnosed with Cushing's disease 35 yr earlier at the age of 14 yr and had undergone bilateral adrenalectomy. Six years later she developed Nelson's syndrome, which was treated with resection of a pituitary adenoma followed by radiotherapy to the sella turcica. Eight years later she was found to have craniospinal metastases with three remote intracerebral lesions. Two of these lesions were surgically resected and stained positive for ACTH by immunofluorescence. She subsequently received whole-brain radiotherapy and is doing well 21 yr later with no lesions seen on magnetic resonance imaging and no evidence of recurrent metastatic disease. We present this case in detail along with a literature review of ACTH-secreting pituitary carcinoma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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