MMP8 Is Increased in Lesions and Blood of Acne Inversa Patients: A Potential Link to Skin Destruction and Metabolic Alterations
| Autor: | Robert Sabat, Kerstin Wolk, A. Tsaousi, Ellen Witte, Wolfram Sterry, Sylke Schneider-Burrus, Katrin Witte, Hans-Dieter Volk, Hans-Joachim Röwert-Huber |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Keratinocytes Male 0301 basic medicine Pathology medicine.medical_specialty Article Subject Biopsy Immunology Enzyme-Linked Immunosorbent Assay Intertriginous Biology 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit MMP8 Pathogenesis 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine lcsh:Pathology medicine Humans Hidradenitis suppurativa Acne Skin medicine.diagnostic_test Tumor Necrosis Factor-alpha Cholesterol HDL Cell Biology Fibroblasts Middle Aged medicine.disease Immunohistochemistry Hidradenitis Suppurativa Matrix Metalloproteinase 8 030104 developmental biology Biomarker (medicine) Female Tumor necrosis factor alpha Biomarkers Research Article Granulocytes lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2016 (2016) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| Popis: | Acne inversa (AI; also designated as hidradenitis suppurativa) is a chronic inflammatory disease with still unknown pathogenesis that affects the intertriginous skin of perianal, inguinal, and axillary sites. It leads to painful nodules, abscesses, and fistulas with malodorous secretion and is frequently associated with metabolic alterations. Here, we demonstrate that one of the most highly upregulated molecules in AI lesions is matrix metalloproteinase 8 (MMP8), an enzyme specialized in the degradation of extracellular matrix components and the HDL component apolipoprotein A-I. Granulocytes, which were present in AI lesions, secreted high amounts of MMP8 especially after TNF-αstimulation. Furthermore, activated fibroblasts but not keratinocytes were found to express MMP8. The high lesional MMP8 levels were accompanied by elevated blood levels that positively correlated with TNF-αblood levels and disease severity assessed by Sartorius score, especially with the number of regions with inflammatory nodules/abscesses and fistulas. Additionally, we found a negative correlation between blood MMP8 and HDL-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in AI. In summary, we demonstrate elevated MMP8 levels in AI lesions, suggest their role in skin destruction and metabolic alterations, and recommend the use of MMP8 as blood biomarker for AI disease activity assessment. |
| Databáze: | OpenAIRE |
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