Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis
| Autor: | Nobuhiro Shimozawa, Fumiko Ono, Michihiro Suzuki, Ryo Kawasaki, Yu Yokoyama, Yusuke Tomiyama, Yusuke Fujii, Kosuke Fujita, Toru Nakazawa, Koji M. Nishiguchi, Toshinori Furukawa, Mutsumi Togo |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine genetic structures Physiology lcsh:Medicine Monkeys Biochemistry Pathogenesis Leukocyte Count Macular Degeneration White Blood Cells Mathematical and Statistical Techniques 0302 clinical medicine Animal Cells Medicine and Health Sciences Geriatric Ophthalmology lcsh:Science Mammals Multidisciplinary medicine.diagnostic_test Retinal Degeneration Age Factors Hematology Body Fluids Blood medicine.anatomical_structure Vertebrates Physical Sciences Retinal Disorders Regression Analysis Female Cellular Types Anatomy Statistics (Mathematics) Research Article Primates medicine.medical_specialty Immune Cells Immunology Retinal Drusen Drusen Research and Analysis Methods 03 medical and health sciences Ocular System Albumins White blood cell Ophthalmology medicine Animals Humans Blood test Statistical Methods Blood Cells Retinal pigment epithelium business.industry lcsh:R Organisms Biology and Life Sciences Proteins Cell Biology Odds ratio Macular degeneration medicine.disease eye diseases Blood Counts Age-related maculopathy Disease Models Animal Macaca fascicularis 030104 developmental biology Geriatrics Macular Disorders Amniotes 030221 ophthalmology & optometry Eyes lcsh:Q sense organs business Head Biomarkers Mathematics |
| Zdroj: | PLoS ONE PLoS ONE, Vol 11, Iss 10, p e0164899 (2016) |
| ISSN: | 1932-6203 |
| Popis: | Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness worldwide. It is established that inflammation contributes to the pathogenesis of drusen and AMD. However, development of a preemptive therapeutic strategy targeting macular drusen and AMD has been impeded by the lack of relevant animal models because most laboratory animals lack macula, an anatomic feature present only in humans and a subset of monkeys. Reportedly, macular drusen and macular degeneration develop in monkeys in an age-dependent manner. In this study, we analyzed blood test results from 945 Macaca fascicularis, 317 with and 628 without drusen. First, a trend test for drusen frequency (the Cochran-Armitage test) was applied to the quartile data for each parameter. We selected variables with an increasing or decreasing trend with higher quartiles at P < 0.05, to which multivariate logistic regression analysis was applied. This revealed a positive association of age (odds ratio [OR]: 1.10 per year, 95% confidence interval [CI]: 1.07-1.12) and white blood cell count (OR: 1.01 per 1 × 103/μl, 95% CI: 1.00-1.01) with drusen. When the monkeys were divided by age, the association between drusen and white blood cell count was only evident in younger monkeys (OR: 1.01 per 1 × 103/μl, 95% CI: 1.00-1.02). In conclusion, age and white blood cell count may be associated with drusen development in M. fascicularis. Systemic inflammation may contribute to drusen formation in monkeys. |
| Databáze: | OpenAIRE |
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