Limited-Sampling Strategies for Therapeutic Drug Monitoring of Moxifloxacin in Patients With Tuberculosis
Autor: | Jan-Willem C. Alffenaar, Arianna D. Pranger, Richard van Altena, Donald R. A. Uges, Tjip S. van der Werf, Rob E. Aarnoutse, Jos G. W. Kosterink |
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Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Targeted Gynaecologic Oncology (TARGON) |
Rok vydání: | 2011 |
Předmět: |
Adult
PHARMACOKINETICS medicine.medical_specialty therapeutic drug monitoring PULMONARY TUBERCULOSIS Population Antitubercular Agents Urology Microbial Sensitivity Tests Pharmacology Invasive mycoses and compromised host [N4i 2] Pharmacokinetics MURINE TUBERCULOSIS Moxifloxacin Tuberculosis Multidrug-Resistant Humans Medicine Pharmacology (medical) Treatment Failure education Ethambutol OFLOXACIN Antibacterial agent Aza Compounds education.field_of_study medicine.diagnostic_test business.industry Mycobacterium tuberculosis IN-VITRO Gatifloxacin tuberculosis Therapeutic drug monitoring limited sampling ETHAMBUTOL Quinolines PHASE-II GATIFLOXACIN MYCOBACTERIUM-TUBERCULOSIS Drug Monitoring moxifloxacin Geometric mean Poverty-related infectious diseases Infectious diseases and international health [N4i 3] business RESISTANCE Fluoroquinolones medicine.drug |
Zdroj: | Therapeutic Drug Monitoring, 33, 3, pp. 350-4 Therapeutic Drug Monitoring, 33, 350-4 Therapeutic Drug Monitoring, 33(3), 350-354. LIPPINCOTT WILLIAMS & WILKINS |
ISSN: | 0163-4356 |
DOI: | 10.1097/ftd.0b013e31821b793c |
Popis: | Background: Moxifloxacin (MFX) is a potent drug for multidrug resistant tuberculosis(TB) treatment and is also useful if first-line agents are not tolerated. Therapeutic drug monitoring may help to prevent treatment failure. Obtaining a full concentration-time curve of MFX for therapeutic drug monitoring is not feasible in most settings. Developing a limited-sampling strategy based on population pharmacokinetics (PK) may help to overcome this problem.Methods: Steady-state plasma concentrations after the administration of 400 mg of MFX once daily were determined in 21 patients with TB, using a validated liquid chromatography-tandem mass spectrometry method. A one-compartment population model was generated and crossvalidated. Monte Carlo data simulation (n = 1000) was used to calculate limited-sampling strategies. The correlation between predicted MFX AUC(0-24h) (area under the concentration-time curve 0 to 24 hours) and observed AUC(0-24h) was investigated by Bland-Altman analysis. Finally, the predictive performance of the final model was tested prospectively using MFX profiles from patients with TB receiving 400, 600, or 800 mg once daily.Results: Median minimum inhibitory concentration of Mycobacterium tuberculosis isolates was 0.25 mg/L (interquartile range: 0.25-0.5 mg/L). The geometric mean AUC(0-24h) was 24.5 mg.h/L (range: 8.5-72.2 mg.h/L), which resulted in a geometric mean AUC(0-24h)/minimum inhibitory concentration ratio of 72 (range: 21-321). PK analysis, based on PK profiles of 400 mg of MFX once daily, resulted in a crossvalidated population PK model with the following parameters: apparent clearance (Cl) 18.5 +/- 8.6 L/h per 1.85 m(2), V-d 3.0 +/- 0.7 L/kg corrected lean body mass, K-a 1.15 +/- 1.16 h 21, and F was fixed at 1. After the Monte Carlo simulation, the best predicting strategy for MFX AUC(0-24h) for practical use was based on MFX concentrations 4 and 14 hours postdosing (r(2) = 0.90, prediction bias = -1.5%, and root mean square error = 15%).Conclusions: MFX AUC(0-24h) in patients with TB can be predicted with acceptable accuracy for clinical management, using limited sampling. AUC(0-24h) prediction based on 2 samples, 4 and 14 hours postdose, can be used to individualize treatment. |
Databáze: | OpenAIRE |
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