Investigation on the association between NLRP3 gene polymorphisms and susceptibility to primary gout
| Autor: | Yanjie Ding, Qing-Ping Zhao, X. L. Zhang, Wang Lindan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Gout Gastroenterology Polymorphism Single Nucleotide chemistry.chemical_compound Gene Frequency Polymorphism (computer science) Internal medicine NLR Family Pyrin Domain-Containing 3 Protein Genetics Medicine Humans Genetic Predisposition to Disease Molecular Biology Allele frequency Genotyping Alleles Genetic Association Studies Aged business.industry Case-control study General Medicine Middle Aged medicine.disease Endocrinology chemistry Case-Control Studies Uric acid Female business Carrier Proteins Body mass index |
| Zdroj: | Genetics and molecular research : GMR. 14(4) |
| ISSN: | 1676-5680 |
| Popis: | We conducted a case-control study to investigate the association between 3 common NALP3 polymorphisms (rs10754558, rs7512998, and rs12137901) and the susceptibility to primary gout. A total of 320 patients with primary gout and 320 controls were included in this study. The genotyping of NALP3 rs10754558, rs7512998, and rs12137901 were conducted by polymerase chain reaction-restriction fragment length polymorphism. Comparison analysis showed that primary gout patients were more likely to have higher body mass index, prevalence of hypertension, blood glucose, triglycerides, urea nitrogen, and uric acid (P < 0.05). Logistic regression analysis revealed no significant association between the NALP3 rs10754558, rs7512998, and rs12137901 polymorphisms and the risk of gouty arthritis. In conclusion, we found no significant association between NALP3 gene polymorphisms and the risk of primary gout. |
| Databáze: | OpenAIRE |
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