Hand-foot skin reaction with vascular endothelial growth factor receptor tyrosine kinase inhibitors in cancer patients: A systematic review and meta-analysis
Autor: | Jing Li, Jian Gu |
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Rok vydání: | 2017 |
Předmět: |
Oncology
medicine.medical_specialty Vascular Endothelial Growth Factor Receptor MEDLINE law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Neoplasms medicine Humans 030212 general & internal medicine Protein Kinase Inhibitors Skin Vascular Endothelial Growth Factor Receptor-1 business.industry Cancer Hematology medicine.disease Surgery Skin reaction Receptors Vascular Endothelial Growth Factor 030220 oncology & carcinogenesis Relative risk Meta-analysis Hand-Foot Syndrome business Tyrosine kinase |
Zdroj: | Critical reviews in oncology/hematology. 119 |
ISSN: | 1879-0461 |
Popis: | A meta-analysis was conducted to systematically review the risk of hand-foot skin reaction (HFSR) with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs) in patients with cancer. The relevant studies of the randomized controlled trials (RCTs) in cancer patients treated with VEGFR-TKIs were retrieved and the systematic evaluation was conducted. EMBASE, MEDLINE, and PubMed were searched for articles published till May 2017. Twenty-one RCTs and 9552 patients were included. The current analysis suggested that the use of VEGFR-TKIs increased the risk of all-grade HFSR (7.04;95%CI, 5.33-9.30;p |
Databáze: | OpenAIRE |
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