Author Correction: A transgenic approach for controlling Lygus in cotton
| Autor: | Robert S. Brown, Xiaohong Shi, Michael Pleau, Nageotte Jeffrey R, Brent J. Werner, James A. Baum, Thomas L. Clark, Anilkumar Gowda, Stanislaw Flasinski, Andrew C. Read, Wollacott Andrew M, Timothy J. Rydel, Waseem Akbar |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Science
Transgene General Physics and Astronomy Biology General Biochemistry Genetics and Molecular Biology Heteroptera Hemolysin Proteins Bacterial Proteins Animals Lygus Author Correction Pest Control Biological lcsh:Science Gossypium Multidisciplinary Bacillus thuringiensis Toxins business.industry General Chemistry biology.organism_classification Plants Genetically Modified Biotechnology Endotoxins Biological Assay Mutant Proteins lcsh:Q business |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-2 (2020) Nature Communications |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-14789-w |
| Popis: | Lygus species of plant-feeding insects have emerged as economically important pests of cotton in the United States. These species are not controlled by commercial Bacillus thuringiensis (Bt) cotton varieties resulting in economic losses and increased application of insecticide. Previously, a Bt crystal protein (Cry51Aa2) was reported with insecticidal activity against Lygus spp. However, transgenic cotton plants expressing this protein did not exhibit effective protection from Lygus feeding damage. Here we employ various optimization strategies, informed in part by protein crystallography and modelling, to identify limited amino-acid substitutions in Cry51Aa2 that increase insecticidal activity towards Lygus spp. by200-fold. Transgenic cotton expressing the variant protein, Cry51Aa2.834_16, reduce populations of Lygus spp. up to 30-fold in whole-plant caged field trials. One transgenic event, designated MON88702, has been selected for further development of cotton varieties that could potentially reduce or eliminate insecticide application for control of Lygus and the associated environmental impacts. |
| Databáze: | OpenAIRE |
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