Study on anti-metastasis of heparin derivatives as ligand antagonist of p-selectin
| Autor: | Li Zheng, Yongfu Li, Jun-Yong Luo, Hui-Fei Cui, S.-S. Du |
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| Rok vydání: | 2010 |
| Předmět: |
Blood Platelets
Lung Neoplasms P-selectin medicine.drug_class Pharmacology Ligands Glycosaminoglycan Cell Line Tumor medicine Cell Adhesion Humans Platelet Neoplasm Metastasis Cell adhesion Cells Cultured Cell Proliferation Chemistry Cell adhesion molecule Heparin Anticoagulant Antagonist Anticoagulants Endothelial Cells General Medicine Salivary Gland Neoplasms Carcinoma Adenoid Cystic P-Selectin Biochemistry medicine.drug |
| Zdroj: | Biomedicinepharmacotherapy = Biomedecinepharmacotherapie. 64(10) |
| ISSN: | 1950-6007 |
| Popis: | Heparin has a potential value as therapeutic agents that block P-selectin-mediated cell adhesion and prevent tumor metastasis. However, the strong anticoagulant potency limits its applicability for the anti-metastasis activity. Carboxyl and sulfate groups of heparin are closely related to its anticoagulant activity, so seven kinds of heparin derivatives related to carboxyl and sulfate groups were prepared, and their effects on anti-metastasis as ligand antagonist of p-selectin were studied. The results showed that heparin, carboxyl reduction heparin, 2-O-desulfated heparin and N-desulfated- N-acetylated heparin could inhibit the adhesion of tumor cells to endothelial cells and platelets effectively as ligand antagonist of P-selectin. |
| Databáze: | OpenAIRE |
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