Antiviral activity of Win 41258-3, a pyrazole compound, against herpes simplex virus in mouse genital infection and in guinea pig skin infection
| Autor: | W G Gorman, Philip M. Carabateas, P E Came, Francis Pancic, Guy D. Diana, B. A. Steinberg |
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| Jazyk: | angličtina |
| Rok vydání: | 1981 |
| Předmět: |
Male
Microgram viruses Guinea Pigs Skin infection Biology medicine.disease_cause Antiviral Agents Virus Guinea pig Mice Viral Proteins In vivo medicine Animals Pharmacology (medical) Skin Diseases Infectious Cells Cultured Pharmacology Methane sulfonate Herpes Simplex medicine.disease Virology Titer Infectious Diseases Herpes simplex virus Pyrazoles Female Genital Diseases Male Genital Diseases Female Research Article |
| Popis: | Win 41258-3 (4-[6-(2-chloro-4-methoxyphenoxy)hexyl]-3,5-diethyl-1H-pyrazole methane sulfonate) has in vitro and in vivo activity against herpes simplex virus types 1 and 2. In cell culture, a concentration of 2 microgram/ml produced a greater than 50% inhibition of plaque formation of herpes simplex virus type 2, and 3 microgram/ml produced a 100% reduction of herpes simplex virus type 1. Win 41258-3 was effective against herpes simplex virus types 1 and 2 in mouse genital infection after intravaginal administration. Win 41258-3 was administered to mice at 4 h postinfection with solutions containing 1.25, 2.5, 5, or 10% of the compound in saturated tampons. Therapy resulted in a high survival rate (80 to 100%) of treated animals versus 20 to 30% of placebo-treated controls. Win 41258-3 was also effective in guinea pig skin infection produced by herpes simplex virus type 1. Solutions of 2.5, 5, and 10% Win 41258-3, applied to the skin starting 24 h postinfection, resulted in rapid suppression of development of herpetic vesicles and significant reduction of the virus titers in the lesion sites. |
| Databáze: | OpenAIRE |
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