Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium

Autor: Christopher T. Sempos, Stefan Pilz, Lars Rejnmark, Thor Aspelund, Tom Wilsgaard, Kirsten G. Dowling, Femke Rutters, Ragnar Martin Joakimsen, Natasja M. van Schoor, Winfried März, Maja-Lisa Løchen, Paul Lips, Kevin D. Cashman, Giel Nijpels, Ellisiv B. Mathiesen, Zuzana Škrabáková, Ramon Durazo-Arvizu, Vilmundur Gudnason, Martin Gaksch, Inger Njølstad, Esther van 't Riet, Mairead Kiely, Michael Thamm, Karin M. A. Swart, Diana Grove-Laugesen, Henrik Schirmer, Christa Scheidt-Nave, Ingeborg A. Brouwer, Tamara B. Harris, Marcus E. Kleber, Elias F. Gudmundsson, Gert B. M. Mensink, Guri Grimnes, Markus A. Busch, Gudny Eiriksdottir, Rolf Jorde, Andreas Tomaschitz, Mary Frances Cotch, Jacqueline M. Dekker, Martin R. Grübler, Joline W.J. Beulens
Přispěvatelé: Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, General practice, APH - Societal Participation & Health, APH - Aging & Later Life, Internal medicine, APH - Personalized Medicine, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, Læknadeild (HÍ), Faculty of Medicine (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Nutrition and Health, APH - Mental Health
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Gerontology
Male
Dánartíðni
D vítamín
Organic chemistry
lcsh:Medicine
Blood Pressure
Cardiovascular Medicine
Vascular Medicine
Cohort Studies
0302 clinical medicine
Mathematical and Statistical Techniques
Endocrinology
Medicine and Health Sciences
030212 general & internal medicine
Prospective Studies
Blóðrásarsjúkdómar
Vitamin D
Prospective cohort study
lcsh:Science
2. Zero hunger
education.field_of_study
Public health
Multidisciplinary
Death rates
VDP::Medical disciplines: 700::Clinical medical disciplines: 750
Mortality rate
Hazard ratio
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750
Vitamins
Middle Aged
Reference Standards
3. Good health
Europe
Survival Rate
Physical sciences
Chemistry
Nutritional deficiencies
Cardiovascular diseases
Cardiovascular Diseases
Research Design
Hypertension
Deficiency
Female
Statistics (Mathematics)
Research Article
medicine.medical_specialty
Death Rates
Endocrine Disorders
Population
030209 endocrinology & metabolism
Research and Analysis Methods
vitamin D deficiency
03 medical and health sciences
Chemical compounds
SDG 3 - Good Health and Well-being
Internal medicine
Organic compounds
medicine
Vitamin D and neurology
Diabetes Mellitus
Journal Article
Humans
Risk factor
Statistical Methods
Mortality
education
Survival rate
Aged
Demography
Nutrition
Vitamin D deficiency
Biology and life sciences
business.industry
lcsh:R
Rannsóknir
medicine.disease
Metabolic Disorders
People and Places
570 Life sciences
biology
lcsh:Q
business
Mathematics
Meta analysis
Meta-Analysis
Zdroj: PLoS ONE, Vol 12, Iss 2, p e0170791 (2017)
PLoS ONE, 12(2):e0170791. Public Library of Science
Gaksch, Martin; Jorde, Rolf; Grimnes, Guri; Joakimsen, Ragnar; Schirmer, Henrik; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Njølstad, Inger; Løchen, Maja-Lisa; März, Winfried; Kleber, Marcus E.; Tomaschitz, Andreas; Grübler, Martin; Eiriksdottir, Gudny; Gudmundsson, Elias F.; Harris, Tamara B.; Cotch, Mary F.; Aspelund, Thor; Gudnason, Vilmundur; Rutters, Femke; ... (2017). Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium. PLoS ONE, 12(2), e0170791. Public Library of Science 10.1371/journal.pone.0170791
PLoS ONE
Gaksch, M, Jorde, R, Grimnes, G, Joakimsen, R, Schirmer, H, Wilsgaard, T, Mathiesen, E B, Njølstad, I, Løchen, M-L, März, W, Kleber, M E, Tomaschitz, A, Grübler, M, Eiriksdottir, G, Gudmundsson, E F, Harris, T B, Cotch, M F, Aspelund, T, Gudnason, V, Rutters, F, Beulens, J W J, van 't Riet, E, Nijpels, G, Dekker, J M, Grove-Laugesen, D, Rejnmark, L, Busch, M A, Mensink, G B M, Scheidt-Nave, C, Thamm, M, Swart, K M A, Brouwer, I A, Lips, P, van Schoor, N M, Sempos, C T, Durazo-Arvizu, R A, Škrabáková, Z, Dowling, K G, Cashman, K D, Kiely, M & Pilz, S 2017, ' Vitamin D and mortality : Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium ', PLoS ONE, vol. 12, no. 2, e0170791, pp. e0170791 . https://doi.org/10.1371/journal.pone.0170791
Gaksch, M, Jorde, R, Grimnes, G, Joakimsen, R, Schirmer, H, Wilsgaard, T, Mathiesen, E B, Njølstad, I, Løchen, M-L, März, W, Kleber, M E, Tomaschitz, A, Grübler, M, Eiriksdottir, G, Gudmundsson, E F, Harris, T B, Cotch, M F, Aspelund, T, Gudnason, V, Rutters, F, Beulens, J W, van 't Riet, E, Nijpels, G, Dekker, J M, Grove-Laugesen, D, Rejnmark, L, Busch, M A, Mensink, G B M, Scheidt-Nave, C, Thamm, M, Swart, K M A, Brouwer, I A, Lips, P, van Schoor, N M, Sempos, C T, Durazo-Arvizu, R A, Škrabáková, Z, Dowling, K G, Cashman, K D, Kiely, M & Pilz, S 2017, ' Vitamin D and mortality : Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium ', PLOS ONE, vol. 12, no. 2, pp. e0170791 . https://doi.org/10.1371/journal.pone.0170791
Gaksch, M, Jorde, R, Grimnes, G, Joakimsen, R, Schirmer, H, Wilsgaard, T, Mathiesen, E B, Njølstad, I, Løchen, M L, Maürz, W, Kleber, M E, Tomaschitz, A, Gruübler, M, Eiriksdottir, G, Gudmundsson, E F, Harris, T B, Cotch, M F, Aspelund, T, Gudnason, V, Rutters, F, Beulens, J W J, Van't Riet, E, Nijpels, G, Dekker, J M, Grove-Laugesen, D, Rejnmark, L, Busch, M A, Mensink, G B M, Scheidt-Nave, C, Thamm, M, Swart, K M A, Brouwer, I A, Lips, P, Van Schoor, N M, Sempos, C T, Durazo-Arvizu, R A, Škrabaókovaó, Z, Dowling, K G, Cashman, K D, Kiely, M & Pilz, S 2017, ' Vitamin D and mortality : Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium ', PLoS ONE, vol. 12, no. 2, e0170791 . https://doi.org/10.1371/journal.pone.0170791
ISSN: 0243-8488
1932-6203
Popis: Background Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D) concentrations and used aggregate data instead of individual participant data (IPD). We therefore performed an IPD meta-analysis on the association between standardized serum 25(OH)D and mortality. Methods In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP) protocols to standardize 25(OH)D data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OH)D with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488. Findings We analysed 26916 study participants (median age 61.6 years, 58% females) with a median 25(OH)D concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OH)D concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval) for mortality in the 25(OH)D groups with 40 to 49.99, 30 to 39.99, and
This project has received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under Grant Agreement 613977 for the ODIN Integrated Project [Food-based solutions for optimal vitamin D nutrition and health through the life cycle http://www.odin-vitd.eu/]. Funding for the individual studies contributing data to this effort can be found in Appendix (S1 File), section 11.
Databáze: OpenAIRE
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