TWIST1, MMP‐21, and HLAG‐1 co‐overexpression is associated with ESCC aggressiveness
| Autor: | Fatemeh Fardi Golyan, Mohammad Reza Abbaszadegan, Mohammad Mahdi Forghanifard |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine animal structures Esophageal Neoplasms Lymphovascular invasion Biology Biochemistry Metastasis 03 medical and health sciences 0302 clinical medicine Matrix Metalloproteinases Secreted Gene expression Biomarkers Tumor medicine Humans Clinical significance Molecular Biology Aged Retrospective Studies Aged 80 and over HLA-G Antigens Messenger RNA Twist-Related Protein 1 Nuclear Proteins Cancer Cell Biology Middle Aged Prognosis medicine.disease Gene Expression Regulation Neoplastic 030104 developmental biology Real-time polymerase chain reaction Tumor progression Lymphatic Metastasis 030220 oncology & carcinogenesis Cancer research Female Esophageal Squamous Cell Carcinoma Follow-Up Studies |
| Zdroj: | Journal of Cellular Biochemistry. 120:14838-14846 |
| ISSN: | 1097-4644 0730-2312 |
| Popis: | Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive types of cancer, requiring reliable biomarkers for prognosis and therapeutic responsiveness. TWIST1, as an important factor responsible for metastasis of several cancers, is involved in tumor invasion and metastasis through indirectly regulation of MMP-21 expression. On the other hand, NF-ĸβ which is a regulator of HLAG-1 has direct interaction with TWIST1 protein. In this retrospective study we investigated the clinical significance of TWIST1, MMP-21, and HLAG-1 expression in ESCC, and the possible correlation between these genes and progression of the disease. The gene expression analyses of TWIST1, MMP-21, and HLA-G1 were performed by relative comparative real-time polymerase chain reaction in 58 ESCCs compared with corresponding margin-normal esophageal tissues. Significant overexpression of HLAG-1, TWIST1, and MMP-21 messenger RNA was observed in 22.4%, 41.4%, and 60.3% of tumor samples, respectively. Concomitant overexpression of TWIST1/MMP-21 and TWIST1/HLAG-1 were significantly correlated to each other in various clinicopathological features, including depth of tumor invasion, stage of tumor progression, lymphatic invasion, and grade of tumor cell differentiation ( P < 0.05). The current study is the first report of coexpression of TWIST1, MMP-21, and HLAG-1 in ESCC. Such findings suggest an oncogenic role for concomitant expression of these genes in ESCC invasion and metastasis. |
| Databáze: | OpenAIRE |
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