Human Reovirus-like Agent as the Major Pathogen Associated with 'Winter' Gastroenteritis in Hospitalized Infants and Young Children
| Autor: | W. Lee Cline, Julita O. Arrobio, David A. Sack, William J. Rodriguez, Richard G. Wyatt, Albert Z. Kapikian, Robert H. Parrott, Carl D. Brandt, Robert M. Chanock, Hyun Wha Kim |
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| Rok vydání: | 1976 |
| Předmět: |
Diarrhea
Male Serotype medicine.medical_specialty Adolescent Enterotoxin Antibodies Viral Reoviridae Adenoviridae Serology Enterotoxins Feces Internal medicine Escherichia coli Humans Medicine Child Pathogen business.industry Complement Fixation Tests Infant Newborn Infant General Medicine Acute gastroenteritis Gastroenteritis Reoviridae Infections Child Preschool Acute Disease Immunology Etiology Female Seasons medicine.symptom business Antibody formation |
| Zdroj: | New England Journal of Medicine. 294:965-972 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm197604292941801 |
| Popis: | We found a human reovirus-like agent in the stools of 42 per cent of 143 infants and young children hospitalized with acute gastroenteritis between January, 1974, and June, 1975. Half the patients studied by electron microscopy and serologic technics had evidence of infection with the agent. The infection had a seasonal pattern: 59 per cent of those admitted during the cooler months (November to April) shed the agent, with a peak of 78 per cent in December, 1974, and January, 1975, combined. None of the patients admitted during the warmer months (May to October) shed the agent. None of 275 Escherichia coli isolates from 32 patients with diarrhea produced heat-labile enterotoxin, whereas 17 of the 32 had evidence of infection with the reovirus-like agent. In addition, 14 of 40 parents of 37 patients with diarrhea associated with the reovirus-like agent were also infected, but most infectious were inapparent. This agent appears to be the major cause of diarrheal illness in the young during the cooler months. |
| Databáze: | OpenAIRE |
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