Highly purified omega-3 fatty acids for secondary prevention of sudden cardiac death after myocardial infarction-aims and methods of the OMEGA-study
| Autor: | Bernhard Rauch, Rudolf Schiele, Steffen Schneider, Helmut Gohlke, Frank Diller, Martin Gottwik, Gerhard Steinbeck, Tobias Heer, Hugo Katus, Reinhilde Zimmer, Ali Erdogan, Conrad Pfafferott, Jochen Senges for the OMEGA-Study Group |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Heart disease medicine.medical_treatment Myocardial Infarction Revascularization Sudden death law.invention Sudden cardiac death Randomized controlled trial Double-Blind Method law Heart Rate Internal medicine Fatty Acids Omega-3 medicine Humans Pharmacology (medical) cardiovascular diseases Myocardial infarction Pharmacology business.industry Depression Heart General Medicine medicine.disease Regimen Death Sudden Cardiac Anesthesia Conventional PCI Cardiology Electrocardiography Ambulatory Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular drugs and therapy. 20(5) |
| ISSN: | 0920-3206 |
| Popis: | During the last decades a large body of data has been accumulated indicating omega-3 fatty acids to exert beneficial effects on the prognosis of patients with cardiovascular disease. Especially, omega-3 fatty acids are regarded to be effective in reducing the risk of sudden cardiac death after acute myocardial infarction. However, treatment of acute myocardial infarction and secondary prevention considerably have been improved within the past years including early revascularization by PCI, the routine use of beta-blockers, statins and ACE-inhibitors as well as cardiac rehabilitation for improving life style measures. To date, there exists no controlled randomized trial testing the prognostic effect of omega-3 fatty acids after acute myocardial infarction in a double blind regimen under the conditions of modern treatment of myocardial infarction.The present study therefore evaluates the effect of highly purified omega-3 fatty acid ethylesters (omega-3-acid ethyl esters 90=Zodin) on the rate of sudden cardiac death within 1 year after acute myocardial infarction. Secondary endpoints are total mortality, non-fatal cardiovascular events, rhythm abnormalities in holter monitoring and depression score.The recruitment-period started in October 2003 and is expected to last until December 2006. The results of the study are therefore expected for the beginning of 2008, when all patients will have completed the 12-months follow up-period. |
| Databáze: | OpenAIRE |
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