THE PREVENTION BY SULPHYDRYL COMPOUNDS OF THE TOXICITY IN THE CAT OF 2,6-DIMETHOXYPHENOL AND ITS MORPHOLINOPROPIONYL ESTER
| Autor: | D R Maxwell, A H Loveless |
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| Rok vydání: | 1975 |
| Předmět: |
Male
Methyl Ethers Hydrochloride Morpholines Pyrogallol Pharmacology Mice chemistry.chemical_compound Dogs Species Specificity medicine Animals Cysteine Sulfhydryl Compounds Short duration CATS Chemistry Phenyl Ethers Poisoning Dimercaprol Macaca mulatta Acute toxicity Rats Anesthesia Toxicity Cats Female Cysteamine Rabbits Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 53:93-98 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1975.tb07334.x |
| Popis: | 1 Intravenous (minus)-2,6-dimethoxyphenyl-2-morpholinopropionate hydrochloride (M&B 16,573) produced anaesthesia of short duration in the mouse, rat, rabbit, cat, dog and monkey. In the cat but not in other species, a severe and usually fatal toxic reaction was seen 1-2 h after administration. 2 This toxic reaction but not the anaesthetic properties of M&B 16,573 was prevented by the intravenous administration of cysteine or N-acetylcysteine. Cysteamine or dimercaprol were ineffective. 3 Intravenous administration of 2,6-dimethoxyphenol or 2,6-dimethoxyquinol in the cat produced a response similar to the delayed toxic effects of M&B 16,573 but not preceded by anaesthesia. The toxic effects of these compounds were prevented by cysteine. 4 Intravenous 4-allyl-2,6-dimethoxyphenyl-2-morpholinopropionate hydrochloride produced anaesthesia in the cat without the delayed toxic effects seen after M&B 16,573. 5 The acute toxicity of 2,6-dimethoxyquinol in mice was reduced by the administration of cysteine or N-acetylcysteine. 6 It is postulated that the delayed effects produced by M&B 16,573 in the cat are due to the formation of 2,6-dimethoxyquinol and 2,6-dimethoxybenzoquinone in this species, the toxicity of the latter being reduced by sulphydryl compounds. |
| Databáze: | OpenAIRE |
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