Gastrointestinal Motility, Muscle Relaxation, Antipyretic and Acute Toxicity Screening of Amyrin Type Triterpenoid (Daturaolone) Isolated From Datura metel Linnaeus (Angel’s Trumpet) Fruits
| Autor: | Abdur Rauf, Saud Bawazeer, Sami Bawazeer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Amyrin medicine.drug_class gastrointestinal motility muscle relaxation activity 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine daturaolone medicine Potency Pharmacology (medical) Antipyretic Original Research Pharmacology biology Traditional medicine lcsh:RM1-950 Muscle relaxant biology.organism_classification Acute toxicity 030104 developmental biology Muscle relaxation lcsh:Therapeutics. Pharmacology chemistry Gastrointestinal disorder 030220 oncology & carcinogenesis Datura metel antipyretic activity medicine.drug |
| Zdroj: | Frontiers in Pharmacology, Vol 11 (2020) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2020.544794/full |
| Popis: | Datura metel Linn is used in traditionally for treatment of various diseases including; wound healing, relaxation of smooth muscles, relive fever, as well as gastrointestinal disorder. The gastrointestinal, fever and muscle pain are the public problems, which are treated with different synthetic medicine, which are accompaniedaccompanying with several side effects. The phytochemicals have gained promising importance over synthetic medicine (drug). This study deals with the bio-guided isolation of an active, amyrin type triterpenoid namely 3-oxo-6-β-hydroxy-β-amyrin (daturaolone; 1), from chloroform fraction of Datura metel L. (Angel’s trumpet) fruits and it was also concerned with the its in -vivo evaluation in gastrointestinal motility, antipyretic and muscle relaxation in animal models study.The chemical structure of daturaolone (1) was elucidated by advanced NMR and crystallography techniques. The chloroform extract fraction and daturaolone (1) isolated from D. metel were assessed for the GIT motilityscreening test. Data exhibited in charcoal meal GI transit test that Results showed the chloroform fraction e fraction and daturaolone (1) in charcoal meal GI transit screening showed significantly reducetion of GIT motility and an increase in intestinal transit time, comparable to standard (atropine), a muscarinic receptor blocking agent. Thus the extract and daturaolone (1) showed a strong dose-dependent reduction in GIT motility. The muscle relaxant potency of extract and daturaolone (1), was assessed in various animal paradigms. In the inclined plane screening test, it produced a significant (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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