PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, inhibits anaplastic thyroid carcinoma cell proliferation and migration
| Autor: | Wei-ying Lou, Qiao-ying You, Xu-wei Si, Huan-yong Che, Hang-yuan Guo |
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| Rok vydání: | 2014 |
| Předmět: |
Time Factors
Cell Survival Blotting Western Mice Nude Apoptosis Biology Thyroid Carcinoma Anaplastic Phosphatidylinositol 3-Kinases Cell Movement Cell Line Tumor medicine Animals Humans Thyroid Neoplasms Tyrosine 1-Phosphatidylinositol 4-Kinase Thyroid cancer Protein kinase B PI3K/AKT/mTOR pathway Cell Proliferation Dose-Response Relationship Drug Kinase Cell growth General Medicine Protein-Tyrosine Kinases medicine.disease Immunohistochemistry Xenograft Model Antitumor Assays Tumor Burden Cell biology Pyrimidines Microscopy Fluorescence Cancer cell Pyrazoles Signal transduction Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Tumor Biology. 35:8659-8664 |
| ISSN: | 1423-0380 1010-4283 |
| DOI: | 10.1007/s13277-014-2118-3 |
| Popis: | The tyrosine and phosphoinositide kinases play crucial roles in the regulation of many cancer cell processes including cell survival and cell motility. Anaplastic thyroid carcinoma (ATC) is a rare and deadly type of thyroid cancer, and so far, there are no effective therapeutic compounds for ATC. Herein, we investigate the anticancer activities of PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, in ATC therapy. We found that PP121 is effective at suppressing cell viability, inducing cell apoptosis, and inhibiting cell migration and invasion. The potential anticancer mechanism for PP121 might be its inhibitory effects on phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathways in ATC cells. Furthermore, PP121 is effective at suppressing ATC tumor growth in vivo. In summary, our studies suggest that PP121 might be a promising therapeutic compound for ATC treatment, which might shed new light on ATC therapy. |
| Databáze: | OpenAIRE |
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