Typical type 2 diabetes mellitus and HFE gene mutations: a population-based case - control study
| Autor: | Ian G. McFarlane, Jian'an Luan, Timothy M. Cox, David Halsall, Nicholas J. Wareham |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Heterozygote congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Genotype Population Biology Cohort Studies Gene Frequency Internal medicine Diabetes mellitus Genetics medicine Humans Point Mutation Age of Onset Allele Hemochromatosis Protein education Molecular Biology Allele frequency Genetics (clinical) Hemochromatosis Aged education.field_of_study Histocompatibility Antigens Class I Case-control study Membrane Proteins nutritional and metabolic diseases Type 2 Diabetes Mellitus General Medicine Middle Aged medicine.disease United Kingdom Endocrinology Diabetes Mellitus Type 2 Case-Control Studies Female Age of onset |
| Zdroj: | Human Molecular Genetics. 12:1361-1365 |
| ISSN: | 1460-2083 |
| DOI: | 10.1093/hmg/ddg149 |
| Popis: | Diabetes mellitus is a recognized consequence of hereditary haemochromatosis. Whether the common HFE mutations, that associate with this condition and pre-dispose to increases in serum iron indices, are over-represented in diabetic populations remains controversial. We present data from the largest case-control study of the C282Y and H63D HFE allele frequencies in typical type 2 diabetes mellitus, as defined by an age of onset greater than 30 years and no requirement for insulin in the first year post-diagnosis. We also present a meta-analysis of all similar studies to date. We see no evidence for over-representation of iron loading HFE alleles in type 2 diabetes mellitus, suggesting that screening for HFE mutations in this population is of no value. |
| Databáze: | OpenAIRE |
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