MUC2 but not MUC5 expression correlates with prognosis in radically resected pancreatic cancer patients
| Autor: | Francesco Pantano, Michele Caraglia, Federica Castri, Armando Antinori, Alfonso Baldi, Domenico Borzomati, Paolo Magistrelli, Roberto Coppola, Bruno Vincenzi, Daniele Santini, Fabio Maria Vecchio, Giuseppe Tonini |
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| Přispěvatelé: | Pantano, F, Baldi, Alfonso, Santini, D, Vincenzi, B, Borzomati, D, Vecchio, Fm, Castri, F, Antinori, A, Caraglia, Michele, Magistrelli, P, Coppola, R, Tonini, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Adult Male Cancer Research medicine.medical_specialty Prognosi Kaplan-Meier Estimate Adenocarcinoma medicine.disease_cause digestive system Cohort Studies Pancreatic cancer Internal medicine medicine Biomarkers Tumor Humans Gastrointestinal cancer Aged Pharmacology Aged 80 and over Univariate analysis Mucin-2 pancreas cancer surgery prognosis business.industry Proportional hazards model respiratory system Middle Aged medicine.disease Prognosis Immunohistochemistry Mucin-5B digestive system diseases Pancreatic Neoplasms MUC5 MUC2 Mucin Molecular Medicine CA19-9 Female Pancreatic ductal business Carcinogenesis |
| Zdroj: | Scopus-Elsevier |
| Popis: | Introduction: Pancreatic cancer is one of the most aggressive gastrointestinal cancer with less than 10% long-term survivors. The apoptotic pathway deregulation is a postulated mechanism of carcinogenesis of this tumor. The present study investigated the prognostic role of MUC2 and MUC5 apomucin expression in a series of surgically resected pancreatic cancer patients. Results: By univariate analysis, survival was influenced by MUC2 expression but not by MUC5 expression. The MUC2 overexpression was associated with better prognosis (p = 0.003). By a multivariate Cox regression analysis, MUC2 overexpression maintained the prognostic statistical value. In particular, patients with high MUC2 staining showed a longer survival. Moreover the present study does report the absence of a prognostic role of MUC5 expression in this type of cancer. Material and methods: All patients affected by pancreatic ductal adenocarcinoma and treated with surgical resection from 1988-2003 were considered for the study. MUC2 and MUC5 expression were evaluated by immunohistochemical staining. Tumor specimens of 59 resected patients were included in the study. Conclusions: the study demonstrated the prognostic relevance of MUC2 expression in pancreatic cancer and underlined its potential role as target gene in the field of therapy research. ©2009 Landes Bioscience. |
| Databáze: | OpenAIRE |
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