Association between serum trans-monounsaturated fatty acids and breast cancer risk in the E3N-EPIC Study
| Autor: | Anne C. M. Thiébaut, Véronique Chajès, Virginie Maillard, Françoise Clavel-Chapelon, Gilbert M. Lenoir, Estelle Gauthier, Virginie Joulin, Maxime Rotival, Marie-Christine Boutron-Ruault |
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| Přispěvatelé: | Clavel-Chapelon, F., Génomes et cancer (GC (FRE2939)), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Centre National de la Recherche Scientifique (CNRS), Nutrition, hormones et cancer: épidémiologie et prévention (E3N), Epidémiologie, sciences sociales, santé publique (IFR 69), Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris 1 Panthéon-Sorbonne (UP1)-Université Paris-Sud - Paris 11 (UP11)-École des hautes études en sciences sociales (EHESS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), This study was supported by grants from the Fondation de France and Fondation Carrefour. The E3N Study is being carried out with the financial support of the French League Against Cancer, the European Community, the 3M Company, Mutuelle Générale de l'Education Nationale, the French Institute of Health and Medical Research, the Gustave Roussy Institute, and several general councils in France. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
030309 nutrition & dietetics
Epidemiology Physiology MESH: Logistic Models MESH: Food Habits Oleic Acids Fatty Acids Monounsaturated chemistry.chemical_compound 0302 clinical medicine Surveys and Questionnaires Palmitoleic acid MESH: Incidence Prospective Studies chemistry.chemical_classification MESH: Aged 0303 health sciences MESH: Middle Aged MESH: Risk Incidence MESH: Chromatography Gas Middle Aged MESH: Case-Control Studies 3. Good health European Prospective Investigation into Cancer and Nutrition MESH: Fatty Acids Monounsaturated 030220 oncology & carcinogenesis Female Breast disease France trans fatty acids Adult Risk medicine.medical_specialty Chromatography Gas Breast Neoplasms fatty acids Article 03 medical and health sciences Breast cancer Internal medicine medicine Biomarkers Tumor Humans Risk factor Aged MESH: Humans business.industry MESH: Questionnaires MESH: Oleic Acid Fatty acid Cancer MESH: Adult Odds ratio Feeding Behavior medicine.disease MESH: Prospective Studies MESH: France Endocrinology Logistic Models chemistry [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie Case-Control Studies MESH: Tumor Markers Biological [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business diet MESH: Female MESH: Breast Neoplasms Oleic Acid |
| Zdroj: | American Journal of Epidemiology American Journal of Epidemiology, 2008, 167 (11), pp.1312-20. ⟨10.1093/aje/kwn069⟩ American Journal of Epidemiology, Oxford University Press (OUP), 2008, 167 (11), pp.1312-20. ⟨10.1093/aje/kwn069⟩ |
| ISSN: | 0002-9262 1476-6256 |
| DOI: | 10.1093/aje/kwn069⟩ |
| Popis: | International audience; The authors assessed the association between serum phospholipid fatty acids as biomarkers of fatty acid intake and breast cancer risk among women in the E3N Study (1989-2002), the French component of the European Prospective Investigation into Cancer and Nutrition. During an average of 7 years of follow-up, 363 cases of incident invasive breast cancer were documented among 19,934 women who, at baseline (1995-1998), had completed a diet history questionnaire and provided serum samples. Controls were randomly matched to cases by age, menopausal status at blood collection, fasting status at blood collection, date, and collection center. Serum phospholipid fatty acid composition was assessed by gas chromatography. Adjusted odds ratios for risk of breast cancer with increasing levels of fatty acids were calculated using conditional logistic regression. An increased risk of breast cancer was associated with increasing levels of the trans-monounsaturated fatty acids palmitoleic acid and elaidic acid (highest quintile vs. lowest: odds ratio = 1.75, 95% confidence interval: 1.08, 2.83; p-trend = 0.018). cis-Monounsaturated fatty acids were unrelated to breast cancer risk. A high serum level of trans-monounsaturated fatty acids, presumably reflecting a high intake of industrially processed foods, is probably one factor contributing to increased risk of invasive breast cancer in women. |
| Databáze: | OpenAIRE |
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