Antigen-Induced IL-10+ Regulatory T Cells Are Independent of CD25+ Regulatory Cells for Their Growth, Differentiation, and Function
| Autor: | David C. Wraith, Anette Sundstedt, Sophie Minaee, Kirsty S. Nicolson, Emma J. O’Neill, Streeter Heather Barbara |
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| Rok vydání: | 2006 |
| Předmět: |
Immunology
chemical and pharmacologic phenomena T-Lymphocytes Regulatory Article Mice Interleukin 21 Immune Tolerance Animals Immunology and Allergy Cytotoxic T cell IL-2 receptor Antigen-presenting cell Cells Cultured Cell Proliferation Mice Knockout CD40 biology FOXP3 Cell Differentiation Forkhead Transcription Factors Receptors Interleukin-2 hemic and immune systems Natural killer T cell Interleukin-10 Cell biology Phenotype Gene Expression Regulation biology.protein Interleukin 12 |
| Zdroj: | The Journal of Immunology. 176:5329-5337 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.176.9.5329 |
| Popis: | Recent studies have emphasized the importance of T cells with regulatory/suppressor properties in controlling autoimmune diseases. A number of different types of regulatory T cells have been described with the best characterized being the CD25+ population. In addition, it has been shown that regulatory T cells can be induced by specific Ag administration. In this study, we investigate the relationship between peptide-induced, CD4+ regulatory T cells and naturally occurring CD4+CD25+ cells derived from the Tg4 TCR-transgenic mouse. Peptide-induced cells were FoxP3− and responded to Ag by secreting IL-10, whereas CD25+ cells failed to secrete this cytokine. Both cell types were able to suppress the proliferation of naive lymphocytes in vitro although with distinct activation sensitivities. Depletion of CD25+ cells did not affect the suppressive properties of peptide-induced regulators. Furthermore, peptide-induced regulatory/suppressor T cells could be generated in RAG−/−, TCR-transgenic mice that do not spontaneously generate CD25+ regulatory cells. These results demonstrate that these natural and induced regulatory cells fall into distinct subsets. |
| Databáze: | OpenAIRE |
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