Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration
| Autor: | Anne-Marie Carreau, Danielle Xie, Cecilia Diniz Behn, Haseeb Rahat, Melanie Cree-Green, Kristen J. Nadeau, Kai Bartlette, Laura Pyle, Yesenia Garcia-Reyes |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
education.field_of_study
lcsh:QP1-981 business.industry Population Physiology Insulin sensitivity Oral glucose tolerance test medicine.disease Obesity Pediatrics lcsh:Physiology Original Research Paper lcsh:Biochemistry Insulin resistance Mathematical model Protocol dependence medicine lcsh:QD415-436 Behavioral interventions Oral glucose tolerance Test protocol education business |
| Zdroj: | Metabolism Open, Vol 9, Iss, Pp 100078-(2021) Metabolism Open |
| ISSN: | 2589-9368 |
| Popis: | Introduction The Oral Minimal Model (OMM), a differential-equations based mathematical model of glucose-insulin dynamics, utilizes data from a frequently sampled oral glucose tolerance test (OGTT) to quantify insulin sensitivity ( S I ). OMM-based estimates of S I can detect differences in insulin resistance (IR) across population groups and quantify effects of clinical or behavioral interventions. These estimates of S I have been validated in healthy adults using data from OGTTs with durations from 2 to 7 h. However, data demonstrating how protocol duration affects S I estimates in highly IR populations such as adolescents with obesity are limited. Methods A 6-h frequently sampled OGTT was performed in adolescent females with obesity. Two, 3-, and 4- hour implementations of OMM assuming an exponentially-decaying rate of glucose appearance beyond measured glucose concentrations were compared to the 6-h implementation. A 4- hour OMM implementation with truncated data (4h Tr) was also considered. Results Data from 68 participants were included (age 15.8 ± 1.2 years, BMI 35.4 ± 5.6 kg/m2). Although S I values were highly correlated for all implementations, they varied with protocol duration (2h: 2.86 ± 3.31, 3h: 2.55 ± 2.62, 4h: 2.81 ± 2.59, 4h tr: 3.13 ± 3.14, 6h: 3.06 ± 2.85 x 10-4 dl/kg/min per U/ml). S I estimates based on 2 or 3 h of data underestimated S I values, whereas 4-h S I estimates more closely approximated 6-h S I values. Discussion These results suggest that OGTT protocol duration should be considered when implementing OMM to estimate S I in adolescents with obesity and other IR populations. |
| Databáze: | OpenAIRE |
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