Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment
| Autor: | Stephanie O. Breukink, Martijn J.L. Bours, José J.L. Breedveld-Peters, Eline H. van Roekel, Jody van den Ouweland, Fränzel J.B. Van Duijnhoven, Janna L. Koole, Eric T.P. Keulen, Matty P. Weijenberg, Maryska L.G. Janssen-Heijnen |
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| Přispěvatelé: | Epidemiologie, RS: GROW - R1 - Prevention, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Surgery, MUMC+: MA Heelkunde (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty D SUPPLEMENTATION Time Factors Nutrition and Disease Epidemiology Colorectal cancer QUESTIONNAIRE HOSPITAL ANXIETY Hospital Anxiety and Depression Scale DIAGNOSIS 03 medical and health sciences D DEFICIENCY 0302 clinical medicine Cancer Survivors Quality of life Internal medicine HEALTH-RELATED QUALITY Voeding en Ziekte Vitamin D and neurology Humans Medicine Life Science Longitudinal Studies Vitamin D Stage (cooking) Fatigue Depression (differential diagnoses) METAANALYSIS Aged VLAG business.industry CHEMOTHERAPY medicine.disease DEPRESSION DYSFUNCTIONS humanities 030104 developmental biology Oncology 030220 oncology & carcinogenesis Quality of Life Anxiety Female medicine.symptom Colorectal Neoplasms business Blood sampling |
| Zdroj: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 29 (2020) 6 Cancer Epidemiology Biomarkers & Prevention, 29(6), 1135-1144. American Association for Cancer Research Inc. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(6), 1135-1144 |
| ISSN: | 1055-9965 1135-1144 |
| Popis: | Background: Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer survivors. The current study investigated longitudinal associations between serum 25-hydroxyvitamin D3 (25OHD3) concentrations and quality of life in stage I–III colorectal cancer survivors up to 2 years after treatment. Methods: Patients with colorectal cancer (n = 261) were included upon diagnosis. Home visits (including blood sampling) were performed at diagnosis and at 6 weeks, 6 months, 1 year, and 2 years after treatment. Serum 25OHD3 concentrations were measured using LC/MS-MS and adjusted for season. Validated questionnaires were used to assess global quality of life and cognitive functioning (EORTC-QLQ-C30), fatigue (EORTC-QLQ-C30 and Checklist Individual Strength, CIS), and depression and anxiety (Hospital Anxiety and Depression Scale). Statistical analyses were performed using linear mixed models and adjusted for sex, age, time since diagnosis, therapy, comorbidities, physical activity, and body mass index. Results: At diagnosis, 45% of patients were vitamin D deficient ( Conclusions: Higher concentrations of 25OHD3 were longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors. Impact: This study suggests that higher 25OHD3 concentrations may be beneficial for colorectal cancer survivors. Future intervention studies are needed to corroborate these findings. |
| Databáze: | OpenAIRE |
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