Soluble CD95 concentrations are increased in patients with severe systemic lupus erythematosus, but not in their first degree relatives
| Autor: | M W van der Linden, R. G. J. Westendorp, T.W.J. Huizinga, Lucien A. Aarden, T van Lopik |
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| Přispěvatelé: | Other departments, Faculteit der Geneeskunde |
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Systemic disease Cyclophosphamide Immunology macromolecular substances Gastroenterology Severity of Illness Index General Biochemistry Genetics and Molecular Biology Rheumatology Interquartile range Predictive Value of Tests immune system diseases Internal medicine Immunopathology Lupus Erythematosus Cutaneous Immunology and Allergy Medicine Humans Lupus Erythematosus Systemic Genetic Predisposition to Disease fas Receptor First-degree relatives skin and connective tissue diseases Systemic lupus erythematosus Lupus erythematosus business.industry Middle Aged medicine.disease Connective tissue disease Pedigree Extended Report Case-Control Studies Linear Models Female business Biomarkers Immunosuppressive Agents medicine.drug |
| Zdroj: | Annals of the rheumatic diseases, 60(3), 237-241. BMJ Publishing Group Annals of the Rheumatic Diseases, 60(3), 237-241. BMJ Publishing Group |
| ISSN: | 0003-4967 |
| Popis: | OBJECTIVE—Plasma concentrations of soluble CD95 (sCD95) are raised in patients with systemic lupus erythematosus (SLE) before clinical relapses become manifest. Increased sCD95 concentrations may therefore be a familial characteristic that is associated with susceptibility to severe disease. To test this, sCD95 concentrations were measured in healthy first degree relatives of patients with severe and non-severe SLE. METHODS—Seventy seven first degree relatives of 26 patients with severe, and 72 relatives of 25 patients with non-severe lupus were studied. Controls were 42 first degree relatives of 17 patients with chronic cutaneous lupus erythematosus (CCLE) and 63 partners of the patients with their first degree relatives. Severe lupus was defined as both multi-organ disease and cyclophosphamide treatment, non-severe lupus as neither. Organ damage was assessed with the SLICC-ACR index, disease activity with SLEDAI. RESULTS—Soluble CD95 concentrations in relatives of patients with severe SLE were similar to those in relatives of patients with non-severe SLE, relatives of patients with CCLE, and controls (median (interquartile range) sCD95 concentration 0.59 (0.52-0.66) v 0.57 (0.50-0.63), 0.56 (0.51-0.71), and 0.55 (0.49-0.61) ng/ml, p=0.25, p=0.94, and p=0.17, respectively). Increased concentrations of sCD95, however, were found in patients with severe SLE compared with those in patients with non-severe SLE, patients with CCLE, and control relatives (0.77 (0.70-0.97) v 0.60 (0.54-0.67), 0.57 (0.54-0.71), and 0.57 (0.52-0.63) ng/ml, respectively, p |
| Databáze: | OpenAIRE |
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