Effects of Maternal Ethanol Consumption on the Offspring Sensory-Motor Development, Ultrasonic Vocalization, Audiogenic Immobility Reaction and Brain Monoamine Synthesis
| Autor: | Barbara Musi, Sture Liljequist, Ernest Hård, Jörgen A. Engel, Knut Larsson |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Biogenic Amines medicine.medical_specialty Startle response Tyrosine 3-Monooxygenase Offspring Motor Activity Biology Toxicology Immobilization Fetus Sex Factors Pregnancy Dopamine Internal medicine medicine Animals Ultrasonics Amino Acids Pharmacology Ethanol medicine.diagnostic_test Body Weight Brain Rats Inbred Strains medicine.disease Rats Endocrinology Monoamine neurotransmitter Toxicity Gestation Female Serotonin Vocalization Animal medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 56:354-363 |
| ISSN: | 0001-6683 |
| DOI: | 10.1111/j.1600-0773.1985.tb01304.x |
| Popis: | Female rats were given 16% ethanol solution as the sole liquid during the entire period of gestation. At birth the offspring was removed and reared by foster dams consuming normal tap water. The development of sensory motor behaviour and emotional reactions was delayed by 1-2 days in the prenatally ethanol exposed pups as assessed by tests on body righting, acoustic startle response, air righting, rearing and ultrasonic vocalization. In the open-field test the normally occurring behavioural difference between the sexes was not found in the prenatally ethanol exposed pups. Both sexes of the ethanol exposed pups behaved like the female controls suggesting deficient masculinization of the ethanol exposed male pups during foetal age. Biochemical analysis of the brains showed a decreased synthesis of serotonin and dopamine. |
| Databáze: | OpenAIRE |
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