Quantitative I-123-IMP Brain SPECT and Neuropsychoiogical Testing in AIDS Dementia
| Autor: | M. J. Meier, M. C. Foehse, F. S. Rhame, B. C.P. Lee, R. B. Loewenson, Robert J. Boudreau, Christopher C. Kuni, Ren P. Ducret |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male AIDS Dementia Complex Neuropsychological Tests Single-photon emission computed tomography Iodine Radioisotopes Iodine-123 Humans Medicine Dementia Radiology Nuclear Medicine and imaging AIDS dementia Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry Amphetamines Brain General Medicine Iofetamine medicine.disease Intensity (physics) Quartile Neuropsychological testing business Nuclear medicine Emission computed tomography |
| Zdroj: | Clinical Nuclear Medicine. 16:174-177 |
| ISSN: | 0363-9762 |
| DOI: | 10.1097/00003072-199103000-00009 |
| Popis: | We performed I-123-IMP SPECT brain imaging on seven mildly demented AIDS patients and seven normal subjects. In an attempt to detect and quantitate regions of decreased I-123-IMP uptake, pixel intensity histograms of normalized SPECT images at the basal ganglia level were analyzed for the fraction of pixels in the lowest quartile of the intensity range. This fraction (F) averaged 17.5% (S.D. = 4.6) in the AIDS group and 12.6% (S.D. = 5.1) in the normal group (p less than .05). Six of the AIDS patients underwent neuropsychological testing (NPT). NPT showed the patients to have a variety of mild abnormalities. Regression analysis of NPT scores versus F yielded a correlation coefficient of .80 (p less than .05). We conclude that analysis of I-123-IMP SPECT image pixel intensity distribution is potentially sensitive in detecting abnormalities associated with AIDS dementia and may correlate with the severity of dementia as measured by NPT. |
| Databáze: | OpenAIRE |
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