Induction of robust cellular and humoral immunity against SARS-CoV-2 after a third dose of BNT162b2 vaccine in previously unresponsive older adults
| Autor: | Addi J. Romero-Olmedo, Axel Ronald Schulz, Svenja Hochstätter, Dennis Das Gupta, Iiris Virta, Heike Hirseland, Daniel Staudenraus, Bärbel Camara, Carina Münch, Véronique Hefter, Siddhesh Sapre, Verena Krähling, Helena Müller-Kräuter, Marek Widera, Henrik E. Mei, Christian Keller, Michael Lohoff |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult Aged 80 and over Immunity Cellular SARS-CoV-2 T-Lymphocytes Immunology Age Factors Immunization Secondary COVID-19 Cell Biology Middle Aged Antibodies Viral Applied Microbiology and Biotechnology Microbiology Antibodies Neutralizing Immunity Humoral Young Adult Immunogenicity Vaccine Neutralization Tests Immunoglobulin G Genetics Humans BNT162 Vaccine |
| Zdroj: | Nature microbiology |
| ISSN: | 2058-5276 |
| Popis: | Here we compared SARS-CoV-2-specific antibody and T-cell responses between older adults (80 years old, n = 51) and a younger control group (20-53 years old, n = 46) after receiving two doses of BNT162b2. We found that responses in older adults were generally lower, and we identified 10% low-/non-responders. After receiving a third vaccination with BNT162b2, 4 out of 5 low-/non-responders showed antibody and T-cell responses similar to those of responders after two vaccinations. |
| Databáze: | OpenAIRE |
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