SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

Autor: Kenichi Okuda, Alena J. Markmann, Tadaki Suzuki, Sarah R. Leist, Shiho Chiba, Kenneth H. Dinnon, Caitlin E. Edwards, Rhianna E. Lee, Yoshihiro Kawaoka, David M. Margolis, Luther A. Bartelt, Kenta Takahashi, Noriko Nakajima, Makoto Kuroda, Aravinda M. de Silva, Yixuan J. Hou, Rachel L. Graham, Ralph S. Baric, Camille Ehre, Longping V. Tse, Teresa M. Mascenik, Lisa E. Gralinski, Scott H. Randell, Peter Halfmann, Richard C. Boucher, Alexandra Schäfer
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Science
ISSN: 1095-9203
0036-8075
DOI: 10.1126/science.abe8499
Popis: Changing with the timesPandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged from China has now been largely replaced by strains containing the mutation D614G (Asp614-to-Gly) in the viral spike protein. Houet al.compared the characteristics of the new variant against the ancestral form in a series of experiments in human cells and animal models. The variant is better at infecting upper-airway epithelial cells and replicates in greater numbers than the ancestral virus. Evidence indicates modest, if any, significant changes to virulence in animal models. Therefore, the virus appears to have evolved for greater transmissibility in humans rather than for greater pathogenicity. The mutation renders the new virus variant more susceptible to neutralizing antisera without altering the efficacy of vaccine candidates currently under development.Science, this issue p.1464
Databáze: OpenAIRE
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