Coordination of Protein Phosphorylation and Dephosphorylation in Synaptic Plasticity
| Autor: | Mark L. Dell'Acqua, Kevin M. Woolfrey |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Neuronal Plasticity
Synaptic scaling Nonsynaptic plasticity Minireviews Nerve Tissue Proteins Cell Biology Protein tyrosine phosphatase Protein Serine-Threonine Kinases Neurotransmission Biology Synaptic Transmission Biochemistry Cell biology Synaptic plasticity Phosphoprotein Phosphatases Animals Humans Phosphorylation Protein phosphorylation Synaptic signaling Molecular Biology |
| Zdroj: | Journal of Biological Chemistry. 290:28604-28612 |
| ISSN: | 0021-9258 |
| DOI: | 10.1074/jbc.r115.657262 |
| Popis: | A central theme in nervous system function is equilibrium: synaptic strengths wax and wane, neuronal firing rates adjust up and down, and neural circuits balance excitation with inhibition. This push/pull regulatory theme carries through to the molecular level at excitatory synapses, where protein function is controlled through phosphorylation and dephosphorylation by kinases and phosphatases. However, these opposing enzymatic activities are only part of the equation as scaffolding interactions and assembly of multi-protein complexes are further required for efficient, localized synaptic signaling. This review will focus on coordination of postsynaptic serine/threonine kinase and phosphatase signaling by scaffold proteins during synaptic plasticity. |
| Databáze: | OpenAIRE |
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