p53 gene mutation in N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder tumors and N-methyl-N-nitrosourea-induced colon tumors of rats
| Autor: | Akiko Hino, Mitsuo Itakura, Hongzhong Min, Hiroyuki Iwahana, Katsuhiko Yoshimoto, Keisuke Izumi, Eiji Kudo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Gene mutation Biology medicine.disease_cause urologic and male genital diseases Internal medicine medicine Animals Point Mutation Transversion Polymorphism Single-Stranded Conformational Mutation Carcinoma Transitional Cell Bladder cancer Urinary bladder N-butyl-N-(4-hydroxybutyl)nitrosamine Methylnitrosourea p53 gene Exons medicine.disease Genes p53 Rats Inbred F344 digestive system diseases Rats Transitional cell carcinoma Endocrinology medicine.anatomical_structure Oncology Urinary Bladder Neoplasms Colonic Neoplasms Cancer research Adenocarcinoma Rat Butylhydroxybutylnitrosamine sense organs PCR-SSCP Carcinogenesis |
| Zdroj: | Cancer Letters. 117(1):81-86 |
| ISSN: | 0304-3835 |
| Popis: | We analyzed p53 mutations in 17 N-butyl-N-(4-hydroxybutyl) nitrosamine-induced bladder transitional cell carcinomas (TCCs) with or without areas of squamous cell carcinoma (SCC) of Long–Evans Cinnamon (LEC) and F344 rats, and in 7 N-methyl-N-nitrosourea-induced colon adenocarcinomas of LEC rats by polymerase chain reaction-single strand conformation polymorphism analysis and DNA sequencing. Of these bladder tumors, one TCC with moderately differentiated SCC had a T to G transversion mutation at codon 141, leading to a Val to Gly amino acid change. No p53 mutation was found in colon adenocarcinomas. Thus a p53 gene mutation seems infrequent in these rat bladder and colon carcinogenesis models even in the late stage. |
| Databáze: | OpenAIRE |
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