Anti-Inflammatory Therapy for Atherosclerosis: Focusing on Cytokines
Autor: | Gauri Prasad, Andrey V. Grechko, Alexander N. Orekhov, Margarita A. Sazonova, Dwaipayan Bharadwaj, Anastasia V. Poznyak |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.drug_class QH301-705.5 medicine.medical_treatment Anti-Inflammatory Agents Inflammation Disease Review 030204 cardiovascular system & hematology Adaptive Immunity medicine.disease_cause Catalysis Anti-inflammatory Inorganic Chemistry Pathogenesis 03 medical and health sciences 0302 clinical medicine Immunity medicine Animals Humans Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy B cell business.industry Organic Chemistry T cell General Medicine Acquired immune system immunity Computer Science Applications Chemistry 030104 developmental biology Cytokine inflammation Immunology Cytokines medicine.symptom atherosclerosis business Oxidative stress |
Zdroj: | International Journal of Molecular Sciences, Vol 22, Iss 7061, p 7061 (2021) International Journal of Molecular Sciences |
ISSN: | 1661-6596 1422-0067 |
Popis: | Atherosclerosis is a well-known global health problem. Despite the high prevalence of the disease, numerous aspects of pathogenesis remain unclear. Subsequently, there are still no cure or adequate preventive measures available. Atherogenesis is now considered a complex interplay between lipid metabolism alterations, oxidative stress, and inflammation. Inflammation in atherogenesis involves cellular elements of both innate (such as macrophages and monocytes) and adaptive immunity (such as B-cells and T-cells), as well as various cytokines cascades. Because inflammation is, in general, a well-investigated therapeutic target, and strategies for controlling inflammation have been successfully used to combat a number of other diseases, inflammation seems to be the preferred target for the treatment of atherosclerosis as well. In this review, we summarized data on targeting the most studied inflammatory molecular targets, CRP, IL-1β, IL-6, IFN-γ, and TNF-α. Studies in animal models have shown the efficacy of anti-inflammatory therapy, while clinical studies revealed the incompetence of existing data, which blocks the development of an effective atheroprotective drug. However, all data on cytokine targeting give evidence that anti-inflammatory therapy can be a part of a complex treatment. |
Databáze: | OpenAIRE |
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