Alnespirone (S 20499), an Agonist of 5-HT1A Receptors, and Imipramine Have Similar Activity in a Chronic Mild Stress Model of Depression
| Autor: | Mariusz Papp, Carmen Muñoz |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Agonist Imipramine medicine.medical_specialty medicine.drug_class Clinical Biochemistry Drinking Behavior Pharmacology Toxicology Biochemistry Behavioral Neuroscience chemistry.chemical_compound Animal data Internal medicine medicine Animals Alnespirone Spiro Compounds Chronic stress Rats Wistar Biological Psychiatry 5-HT receptor Adrenergic Uptake Inhibitors Dose-Response Relationship Drug Water Deprivation Depression business.industry Rats Serotonin Receptor Agonists Endocrinology chemistry Receptors Serotonin Chronic Disease Antidepressant Onset of action Food Deprivation business Receptors Serotonin 5-HT1 Stress Psychological medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 63:647-653 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/s0091-3057(99)00031-3 |
| Popis: | A chronic mild stress (CMS) model of depression was used to study an antidepressant-like activity of alnespirone (S 20499), a selective agonist of 5-HT1A receptors. In this model, a substantial decrease in consumption of a palatable sucrose solution over time is observed in rats subjected to a variety of mild stressors. This effect can be reversed by chronic administration of various classes of antidepressant drugs. Chronic (5 weeks) treatment with alnespirone, in a dose range between 1-5 mg/kg/day, gradually and dose dependently reversed the CMS-induced reductions in sucrose consumption without any significant effects in the non-stressed control animals. The onset of action of the most active doses (2.5 and 5 mg/kg/day) and the overall efficacy of alnespirone in the CMS model were comparable to those observed following similar administration of imipramine (10 mg/kg/ day). At the lower (0.5 mg/kg/day) and higher (10 and 20 mg/kg/day) doses, alnespirone was ineffective against the CMS-induced deficit in sucrose consumption. These data provide further support for previous suggestions, based on both the clinical observations and animal data, that agonism at 5-HT1A receptors may result in antidepressant action. |
| Databáze: | OpenAIRE |
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