Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer
| Autor: | Balis Me, N.M. Relyea, U. Dunzendorfer, Edward L. Kleinert, Whitmore Wf |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Ornithine Cancer Research medicine.medical_specialty Eflornithine Mitoguazone Therapeutic effectiveness Guanidines Ornithine decarboxylase Prostate cancer Pharmacotherapy Internal medicine medicine Polyamines Animals business.industry Effector Polyamine synthesis Body Weight Prostatic Neoplasms General Medicine Neoplasms Experimental medicine.disease Rats Endocrinology Oncology Cancer research Drug Therapy Combination business Neoplasm Transplantation Vidarabine medicine.drug |
| Zdroj: | Oncology. 40(1) |
| ISSN: | 0030-2414 |
| Popis: | Inhibitors of polyamine synthesis were tested for therapeutic effectiveness on transplantable prostate cancer. Inhibition of either ornithine decarboxylase or S-adenosyl-L-methionine decarboxylase (AMDC) by alpha-difluormethylornithine (DFMO) or methylglyoxal-bis[guanylhydrazone] (MGBG), respectively, was associated with significant antitumor effect. The combination of DFMO with MGBG was not only more effective but no more toxic than MGBG alone. Combination of MGBG with 9-B-D-arabinofuranosyladenine, an indirect effector of SAMDC, failed to increase therapeutic effectiveness of MGBG. |
| Databáze: | OpenAIRE |
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