Effective Population Size Differences in Calomys musculinus, the Host of Junín Virus: Their Relationship with the Epidemiological History of Argentine Hemorrhagic Fever
| Autor: | Marina B. Chiappero, Cristina N. Gardenal, M. F. Piacenza, Gladys E. Calderón, Jaime Polop, María Cecilia Provensal |
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| Rok vydání: | 2018 |
| Předmět: |
0106 biological sciences
0301 basic medicine Population VIRAL TRANSMISSION Zoology Biology Argentine hemorrhagic fever 010603 evolutionary biology 01 natural sciences Ciencias Biológicas Genética y Herencia 03 medical and health sciences ARGENTINE HEMORRHAGIC FEVER Effective population size Virology Genetic variation medicine Genetic variability education education.field_of_study Sigmodontinae CALOMYS MUSCULINUS Population size medicine.disease biology.organism_classification 030104 developmental biology Infectious Diseases Junin virus POPULATION EFFECTIVE SIZE Parasitology CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | The American Journal of Tropical Medicine and Hygiene. 99:445-450 |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.17-0838 |
| Popis: | Argentine hemorrhagic fever (AHF) is a serious endemic disease in Argentina, produced by Junín virus, whose host is the Sigmodontinae rodent Calomys musculinus. Within the endemic area, human incidence and proportion of infected rodents remains high for 5-10 years after the first appearance of the disease (epidemic [E] zone) and then gradually declines to sporadic cases (historic [H] zone). We tested the hypothesis that host populations within the E zone are large and well connected by gene flow, facilitating the transmission and maintenance of the virus, whereas those in the H and nonendemic (NE) zones are small and isolated, with the opposite effect. We estimated parameters affected by levels of gene flow and population size in 14 populations of C. musculinus: population effective size (Ne), genetic variability, and mean relatedness. Our hypothesis was not supported: the lowest levels of variability and of Ne and the highest genetic relatedness among individuals were found in the H zone. Populations from the NE zone displayed opposite results, whereas those in the E zone showed intermediate values. If we consider that populations are first NE, then E, and finally H, a correlative decrease in Ne was observed. Chronically infected females have a low reproductive success. We propose that this would lower Ne because each cohort would originate from a fraction of females of the previous generation, and affect other factors such as proportion of individuals that develop acute infection, probability of viral transmission, and evolution of virulence, which would explain, at least partly, the changing incidence of AHF. Fil: Chiappero, Marina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina Fil: Piacenza, Maria Florencia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Ciencias Naturales; Argentina Fil: Provensal, María Cecilia. Universidad Nacional de Río Cuarto; Argentina Fil: Calderón, Gladys Ethel. Instituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui; Argentina Fil: Gardenal, Cristina Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; Argentina Fil: Polop, Jaime Jose. Universidad Nacional de Río Cuarto; Argentina |
| Databáze: | OpenAIRE |
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