Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing country

Autor: Janjira Thaipadungpanit, Vanaporn Wuthiekanun, Gumphol Wongsuvan, Nicholas P. J. Day, Sharon J. Peacock, Arkhom Arayawichanont, P. Srisamang, Emma K. Nickerson, Premjit Amornchai, Krupal R. Shah, Weera Mahavanakul, Aunchalee Thanwisai, Direk Limmathurosakul
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Infectious Diseases/Epidemiology and Control of Infectious Diseases
Adult
Male
Staphylococcus aureus
medicine.medical_specialty
Adolescent
Bacterial Toxins
Exotoxins
lcsh:Medicine
Disease
medicine.disease_cause
Staphylococcal infections
Infectious Diseases/Bacterial Infections
Young Adult
03 medical and health sciences
0302 clinical medicine
Leukocidins
Internal medicine
Epidemiology
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Intensive care medicine
lcsh:Science
Developing Countries
0303 health sciences
Univariate analysis
Multidisciplinary
Infectious Diseases/Antimicrobials and Drug Resistance
030306 microbiology
business.industry
Mortality rate
lcsh:R
Respiratory infection
Middle Aged
Staphylococcal Infections
medicine.disease
Methicillin-resistant Staphylococcus aureus
Anti-Bacterial Agents
3. Good health
Infectious Diseases
Female
lcsh:Q
business
Research Article
Zdroj: PLoS ONE, Vol 4, Iss 8, p e6512 (2009)
PLoS ONE
ISSN: 1932-6203
Popis: BACKGROUND: Invasive Staphylococcus aureus infection is increasingly recognised as an important cause of serious sepsis across the developing world, with mortality rates higher than those in the developed world. The factors determining mortality in developing countries have not been identified. METHODS: A prospective, observational study of invasive S. aureus disease was conducted at a provincial hospital in northeast Thailand over a 1-year period. All-cause and S. aureus-attributable mortality rates were determined, and the relationship was assessed between death and patient characteristics, clinical presentations, antibiotic therapy and resistance, drainage of pus and carriage of genes encoding Panton-Valentine Leukocidin (PVL). PRINCIPAL FINDINGS: A total of 270 patients with invasive S. aureus infection were recruited. The range of clinical manifestations was broad and comparable to that described in developed countries. All-cause and S. aureus-attributable mortality rates were 26% and 20%, respectively. Early antibiotic therapy and drainage of pus were associated with a survival advantage (both p
Databáze: OpenAIRE
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