High Dietary Fat Intake during Lactation Promotes Development of Diet-Induced Obesity in Male Offspring of Mice
| Autor: | Yasuna Kitano, Tsuyoshi Tsuduki, Ryo Kijima, Taro Honma, Ikuo Ikeda |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Offspring Adipose Tissue White Medicine (miscellaneous) Weaning White adipose tissue Biology Diet High-Fat Mice Lactation Internal medicine medicine Animals Obesity Pregnancy Nutrition and Dietetics Behavior Animal Gene Expression Regulation Developmental Hypertrophy Maternal Nutritional Physiological Phenomena Sterol Esterase Lipid Metabolism medicine.disease Mice Inbred C57BL Lipoprotein Lipase Milk medicine.anatomical_structure Endocrinology Liver Dietary fat intake Female Adipocyte hypertrophy Energy Intake |
| Zdroj: | Journal of Nutritional Science and Vitaminology. 59:384-392 |
| ISSN: | 1881-7742 0301-4800 |
| Popis: | The maternal nutritional status during pregnancy and lactation influences the risk of obesity in offspring, but the details of this phenomenon are unclear. In particular, there is little information on the influence on the offspring of the maternal nutritional status during lactation only. Therefore, in this study, we examined the influence of high dietary fat intake in dams during lactation on the risk of obesity in offspring, using C57BL/6J mice. The mice were fed a control diet (CD) during pregnancy. After birth, dams were fed a CD or a high-fat diet (HD) during lactation (3 wk). Fat and energy were significantly increased in milk from dams fed a HD during lactation. Male offspring were weaned at 3 wk old and fed a CD for 4 wk, which resulted in no significant difference in their physique. Four weeks after weaning, the offspring (7 wk old) were fed a CD or HD for 4 wk to induce obesity. High dietary fat intake in dams and offspring promoted lipid accumulation in white adipose tissue and adipocyte hypertrophy in male offspring. The underlying mechanism may involve an increase in expression of Lpl and a decrease in expression of Hsl in white adipose tissue of offspring. In conclusion, our results show that high dietary fat intake during lactation promotes development of diet-induced obesity in male offspring. |
| Databáze: | OpenAIRE |
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