Somatostatin receptor imaging therapy and new strategies in patients with neuroendocrine tumours
| Autor: | Amir Mearadji, C.H.J. van Eijck, Richard L. Marquet, M. de Jong, G. D. Slooter, Wouter A.P. Breeman, E. P. Krenning |
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| Přispěvatelé: | Surgery, Radiology & Nuclear Medicine |
| Rok vydání: | 2001 |
| Předmět: |
Pathology
medicine.medical_specialty Octreotide Neuroendocrine tumors Transfection Paraganglioma medicine Endocrine system Humans Receptors Somatostatin Receptor Radionuclide Imaging Somatostatin receptor business.industry Indium Radioisotopes Genetic Therapy Pentetic Acid medicine.disease Neuroendocrine Tumors medicine.anatomical_structure Somatostatin Cancer research Surgery Pancreas business medicine.drug |
| Zdroj: | British Journal of Surgery, 88(1), 31-40. John Wiley & Sons Ltd. |
| ISSN: | 1365-2168 0007-1323 |
| DOI: | 10.1046/j.1365-2168.2001.01644.x |
| Popis: | Background Somatostatin receptors have been found on a variety of neuroendocrine tumours, such as carcinoids and paragangliomas, as well as on most pancreatic endocrine and breast tumours. Somatostatin receptor scintigraphy with a radionuclide-labelled somatostatin analogue, [111Indium-diethylenetriaminopenta-acetic acid]octreotide, is a sensitive and specific technique for visualizing in vivo the presence of somatostatin receptors on various tumours. Methods Material was identified from previous review articles, references cited in original papers and a Medline search of the literature. Additional material was obtained from recently published abstracts of meetings. Results and conclusion Somatostatin receptor imaging of neuroendocrine tumours is essential in the diagnostic evaluation of most of these tumours. The expression of somatostatin receptors in vivo not only predicts the outcome of somatostatin analogue treatment but also opens the possibility of new therapeutic strategies. Because better information about spread of the disease can be obtained, more justifiable options for therapy can be proposed. |
| Databáze: | OpenAIRE |
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