Adverse Drug Reactions Attributed to Fondaparinux and Unfractionated Heparin in Cardiovascular Care Unit: An Observational Prospective Pilot Study in a Tertiary Care Hospital
| Autor: | Shubhatara Swamy, Pratibha Nadig, Sahithi Sharma, Anupam Bhambhani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
anticoagulants lcsh:Analytical chemistry lcsh:RS1-441 Bioengineering Cardiovascular care Fondaparinux General Biochemistry Genetics and Molecular Biology lcsh:Pharmacy and materia medica 03 medical and health sciences 0302 clinical medicine Pharmacovigilance medicine 030212 general & internal medicine Drug reaction General Pharmacology Toxicology and Pharmaceutics lcsh:QD71-142 business.industry Incidence (epidemiology) active surveillance CCU 030206 dentistry Heparin ACS pharmacovigilance Emergency medicine Coronary care unit Observational study Original Article business ADRs medicine.drug |
| Zdroj: | Journal of Pharmacy & Bioallied Sciences Journal of Pharmacy and Bioallied Sciences, Vol 10, Iss 2, Pp 90-95 (2018) |
| ISSN: | 0975-7406 0976-4879 |
| Popis: | Introduction: This study was carried out to collect and analyze the adverse drug reactions (ADRs) reported with use of anticoagulants, heparin and fondaparinux. These drugs are vital in the treatment of unstable coronary artery diseases and emergencies. Materials and Methods: A cross-sectional study with active reporting of ADRs from cardiology and medicine department was conducted. The type of reaction was assessed by Rawlins and Thomson criteria, causality by Naranjo probability scale, severity by modified Hartwig criteria, and preventability by Schumock and Thornton criteria. Result: Of the 67 patients observed, 16 showed ADRs. Fifteen reactions were attributable to unfractionated heparin and one to fondaparinux following assessment by the Naranjo causality scale. Severity of the ADRs assessed by modified Hartwig criteria showed that although 12 of 16 (75%) were mild, 4 (25%) were moderate in severity. Modified Schumock and Thornton criteria showed that 9 of 16 (56.25%) reactions could not have been prevented whereas 5 (31.25%) were probably preventable and 2 (12.5%) were definitely preventable. Conclusion: Incidence of ADRs with fondaparinux was lower than with heparin, hence emphasizing its better safety profile. The study also highlights the need for nurses and other caretakers in the coronary care unit to enquire for and report ADRs, particularly with high-potency medicines that are associated with an equally high potential to induce ADRs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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