Pharmacokinetic Modelling of a Parent Drug and its Metabolite
| Autor: | Vladimir Nigrovic, Mark Banoub |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Drug
Metabolic Clearance Rate medicine.drug_class media_common.quotation_subject Metabolite Central compartment Pharmacology Models Biological Laudanosine chemistry.chemical_compound Pharmacokinetics Atracurium besilate medicine Humans Pharmacology (medical) media_common Chromatography Chemistry Temperature Muscle relaxant Hydrogen-Ion Concentration Isoquinolines High plasma Atracurium medicine.drug |
| Zdroj: | Clinical Pharmacokinetics. 22:396-408 |
| ISSN: | 0312-5963 |
| Popis: | A pharmacokinetic model was designed to describe simultaneously the plasma concentrations of atracurium and its metabolite laudanosine. The proposed model satisfactorily fits the observations and is based on the assumptions that the parent drug spontaneously degrades to laudanosine at the rate comparable with that observed in vitro at pH 7.4 and 37 degrees C; that 2 molecules of laudanosine are formed from 1 molecule of atracurium; that an initial very rapid decay of a fraction of the atracurium dose is responsible for the initially high plasma laudanosine concentrations; that the rapid disappearance of atracurium from plasma is accounted for by its spontaneous degradation and by the sequestration of atracurium in a deep compartment; and that laudanosine formed from atracurium is added to its central compartment, with its disposition described by a simple 2-compartment model with elimination from the central compartment. The model projects that about 43% of the atracurium dose is rapidly converted to laudanosine and that nearly the whole injected amount of atracurium is degraded to laudanosine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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