Biologically Inspired Collagen/Apatite Composite Biomaterials for Potential Use in Bone Tissue Regeneration—A Review
| Autor: | Joanna Kolmas, Barbara Kołodziejska, Agnieszka Kaflak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
collagen
Scaffold biocomposite Biocompatibility Review 02 engineering and technology scaffold 010402 general chemistry Bone tissue 01 natural sciences lcsh:Technology bone regeneration medicine General Materials Science Bone regeneration lcsh:Microscopy lcsh:QC120-168.85 lcsh:QH201-278.5 Chemistry lcsh:T Regeneration (biology) Biomaterial hydroxyapatite biomimetic material 021001 nanoscience & nanotechnology Controlled release 0104 chemical sciences medicine.anatomical_structure lcsh:TA1-2040 lcsh:Descriptive and experimental mechanics lcsh:Electrical engineering. Electronics. Nuclear engineering 0210 nano-technology lcsh:Engineering (General). Civil engineering (General) lcsh:TK1-9971 Type I collagen Biomedical engineering |
| Zdroj: | Materials, Vol 13, Iss 1748, p 1748 (2020) Materials |
| ISSN: | 1996-1944 |
| Popis: | Type I collagen and nanocrystalline-substituted hydroxyapatite are the major components of a natural composite—bone tissue. Both of these materials also play a significant role in orthopedic surgery and implantology; however, their separate uses are limited; apatite is quite fragile, while collagen’s mechanical strength is very poor. Therefore, in biomaterial engineering, a combination of collagen and hydroxyapatite is used, which provides good mechanical properties with high biocompatibility and osteoinduction. In addition, the porous structure of the composites enables their use not only as bone defect fillers, but also as a drug release system providing controlled release of drugs directly to the bone. This feature makes biomimetic collagen–apatite composites a subject of research in many scientific centers. The review focuses on summarizing studies on biological activity, tested in vitro and in vivo. |
| Databáze: | OpenAIRE |
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