Epigenetics and DNA Repair in Cancer
Autor: | Marta Elena Hernández-Caballero, María José López-Ibarra |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
DNA repair InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL Cancer Biology medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis medicine Cancer research Epigenetics GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) |
Popis: | Cells can use chemical modifications in chromatin to regulate accessibility to DNA to the repair complexes and to prevent transcription in case of damage. We analyzed the relationship between repair systems and epigenetic mechanisms in DNA and RNA. We searched the PubMed database for genes involved in DNA damage response (DDR) and methylation in mRNA and DNA repair, in cancer. Epigenetic modifications, particularly histone modifications and nucleosome remodeling, trigger a signaling cascade of kinases in DNA damage response (DDR) toward efficient repair. SWI/SNF remodelers promote the recruitment of repair factors in DNA, such as DNA double-strand breaks (DSBs) that activate kinases in DDR. RNA methylation via m6A has recently attracted attention as a possible alternative pathway for repairing DNA damage. m6A is a dynamic methylation mark on mRNA that accumulates after UV irradiation and regulates transcription to facilitate DNA repair. Currently, studies seek to understand how signaling pathways activate proteins in the early response to damage. The repair maintains DNA integrity, which is a challenge in cancer because this process also represents a potential barrier to anticancer agents. The impact that epigenetic regulation can have on DNA repair is beginning to be understood. |
Databáze: | OpenAIRE |
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