Importance of Viral Late Domains in Budding and Release of Enveloped RNA Viruses
Autor: | Jean-Christophe Paillart, Serena Bernacchi, Lisa Welker |
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Přispěvatelé: | Architecture et Réactivité de l'ARN (ARN), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), Université de Strasbourg, CNRS, Architecture et Réactivité de l'ARN |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
ESCRT machinery
viruses Review budding Biology medicine.disease_cause Virus Replication Microbiology ESCRT Conserved sequence viral assembly 03 medical and health sciences late assembly domains Retrovirus Membrane fission RNA enveloped viruses Virology medicine Humans RNA Viruses [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Virus Release 030304 developmental biology 0303 health sciences Budding Mutation Endosomal Sorting Complexes Required for Transport Virus Assembly 030302 biochemistry & molecular biology Ubiquitination Virion RNA biology.organism_classification retroviral gag precursor QR1-502 3. Good health Cell biology structural viral proteins retrovirus Infectious Diseases Viral replication Protein Binding |
Zdroj: | Viruses Viruses, MDPI, 2021, 13 (8), pp.1559. ⟨10.3390/v13081559⟩ Viruses, Vol 13, Iss 1559, p 1559 (2021) |
ISSN: | 1999-4915 |
DOI: | 10.3390/v13081559⟩ |
Popis: | Late assembly (L) domains are conserved sequences that are necessary for the late steps of viral replication, acting like cellular adaptors to engage the ESCRT membrane fission machinery that promote virion release. These short sequences, whose mutation or deletion produce the accumulation of immature virions at the plasma membrane, were firstly identified within retroviral Gag precursors, and in a further step, also in structural proteins of many other enveloped RNA viruses including arenaviruses, filoviruses, rhabdoviruses, reoviruses, and paramyxoviruses. Three classes of L domains have been identified thus far (PT/SAP, YPXnL/LXXLF, and PPxY), even if it has recently been suggested that other motifs could act as L domains. Here, we summarize the current state of knowledge of the different types of L domains and their cellular partners in the budding events of RNA viruses, with a particular focus on retroviruses. |
Databáze: | OpenAIRE |
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