Interaction of lactic acid bacteria with the gut immune system
| Autor: | C. Maldonado Galdeano, J C Valdez, Marta Medici, Gabriela Perdigón |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Lactobacillus casei
Streptococcus thermophilus Medicine (miscellaneous) law.invention Microbiology Interferon-gamma Mice Peyer's Patches Probiotic Lactobacillus acidophilus Immune system law Lactobacillus Intestine Small Animals Mice Inbred BALB C Nutrition and Dietetics biology Tumor Necrosis Factor-alpha Proteins Streptococcus food and beverages T-Lymphocytes Helper-Inducer Lactobacillaceae biology.organism_classification Cytokines bacteria Lactobacillus delbrueckii subsp. bulgaricus |
| Zdroj: | European Journal of Clinical Nutrition. 56:S21-S26 |
| ISSN: | 1476-5640 0954-3007 |
| Popis: | Health claims of lactic acid bacteria (LAB) used in functional foods and pharmaceutical preparations are based on the capacity of these microorganisms to stimulate the host immune system. In this study, the antigenic effect of LAB (Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus delbrueckii ssp. bulgaricus and Streptococcus thermophilus) on the gut immune system of BALB/c mice was evaluated. A dose-dependent increase of the Bcl2 protein was observed with all LAB assayed. Furthermore, the analysis of cytokine-producing cells in the lamina propria of gut showed that TNFalpha and INFgamma values, determined in macrophages cultured from Peyer patches, were enhanced for all the LAB assayed. An important increase of interleukins IL-10 and IL-4 was observed mainly in mice fed with Lactobacillus delbrueckii ssp. bulgaricus or Lactobacillus casei, while a significant induction of IL-2 and IL-12 was only observed with L. acidophilus (P |
| Databáze: | OpenAIRE |
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