Cytomegalovirus in Pediatric Hematopoietic Stem Cell Transplantation: A Case-Based Panel Discussion of Current Challenges

Autor: Danielle M. Zerr, Michael Green, Lara Danziger-Isakov, Klara M. Posfay-Barbe, Janet A. Englund
Rok vydání: 2018
Předmět:
Valganciclovir/therapeutic use
Male
Cytomegalovirus/immunology
Cytotoxic
T-Lymphocytes
medicine.medical_treatment
Drug Resistance
Foscarnet/therapeutic use
Cytomegalovirus
Hematopoietic stem cell transplantation
030230 surgery
Granulomatous Disease
Chronic

Cytomegalovirus Infections/complications/prevention & control/virology
0302 clinical medicine
Fatal Outcome
Recurrence
Secondary Prevention
Medicine
Valganciclovir
Viral
Respiratory Insufficiency/etiology
030212 general & internal medicine
Child
Antiviral Agents/therapeutic use
Secondary prevention
ddc:618
Hematopoietic Stem Cell Transplantation
virus diseases
General Medicine
Viral Load
Infectious Diseases
Cytomegalovirus Infections
Granulomatous Disease
Stem cell
Respiratory Insufficiency
Viral load
Foscarnet
medicine.medical_specialty
Congenital cytomegalovirus infection
Chronic/complications/therapy
Antiviral Agents
Risk Assessment
03 medical and health sciences
Drug Resistance
Viral

Humans
Intensive care medicine
Panel discussion
business.industry
Secondary prophylaxis
medicine.disease
Transplantation
Pediatrics
Perinatology and Child Health

business
T-Lymphocytes
Cytotoxic
Zdroj: Journal of the Pediatric Infectious Diseases Society, Vol. 7, No suppl_2 (2018) pp. S72-S74
ISSN: 2048-7207
2048-7193
Popis: Cytomegalovirus (CMV) remains a significant contributor to morbidity and death after pediatric solid and stem cell transplantation. Decisions regarding prevention and treatment often lack pediatric-specific data to drive decision making. We present here a case-based discussion around some of these specific topics and focus on approaches to CMV prevention, post-CMV secondary prophylaxis options, and identification and treatment of resistant CMV infection, including emerging antiviral agents and the use of cytotoxic CMV-specific T-cells, in the setting of pediatric hematopoietic stem cell transplantation.
Databáze: OpenAIRE
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