Effect of almitrine administration on pulmonary arterial pressure in resting and exercising dogs
| Autor: | Jean-Marc Pequignot, B. Simi, R. Flandrois, J. Frutoso, R. Pagliari, Roland Favier, M. H. Mayet, Dominique Desplanches, B. Sempore |
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| Rok vydání: | 1990 |
| Předmět: |
Pulmonary and Respiratory Medicine
Pulmonary Circulation Almitrine Epinephrine Physiology Haemodynamic response Rest Physical Exertion Hemodynamics Blood Pressure Physical exercise Pulmonary Artery Norepinephrine Dogs Hypoxic pulmonary vasoconstriction Animals Medicine business.industry Carbon Dioxide Oxygen Blood pressure medicine.anatomical_structure Anesthesia Vascular resistance medicine.symptom business Vasoconstriction medicine.drug |
| Zdroj: | Respiration Physiology. 82:75-87 |
| ISSN: | 0034-5687 |
| DOI: | 10.1016/0034-5687(90)90025-t |
| Popis: | In addition to its well-known ventilatory effect, a small rise in pulmonary arterial pressure or pulmonary vascular resistance is occasionally observed with chronic administration of almitrine. In order to test the hypothesis of enhancement of exercise pulmonary vasoconstriction by almitrine, mongrel dogs were studied at rest and during submaximal exercise before and after 4 weeks of chronic ingestion of almitrine (10 mg/kg). It was shown that resting pulmonary arterial pressure (PAP) remained unchanged by almitrine treatment. However, when exercise was superimposed on almitrine medication, PAP was significantly increased throughout the exercise bout. Thus the rise in PAP during the 20th min of exercise averaged 8.7 ± 3.4 mm Hg after almitrine treatment while PAP increased by only 1.3 ± 1.7 mm Hg before medication. The exaggerated exercise-induced PAP response in conjunction with the enhanced secretion of norepinephrine that we observed during almitrine treatment suggests that catecholamine could be involved in the pulmonary haemodynamic adjustments. Furthermore, mixed-venous PO2 (P v O2) both during rest and exercise declined with prolongation of almitrine ingestion, suggesting that P v O2 might possibly be implicated in the pulmonary haemodynamic response to almitrine, in the same way as it is involved in the hypoxia-induced pulmonary vasoconstriction. These findings demonstrate that almitrine condition, even at a high dose, does not have any deleterious effect on pulmonary vasculature in resting conditions, but prolonged submaximal exercise should be proscribed in patients on a long-term therapy. |
| Databáze: | OpenAIRE |
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