Gamma Knife Stereotactic Radiosurgery for Grade 2 Meningiomas
| Autor: | I. Helenowksi, James P. Chandler, Sean Sachdev, Tamer Refaat, Stanley I. Gutiontov, Orin Bloch, John A. Kalapurakal, Anish Butala, Michelle S. Gentile, V. Sathiaseelan, Prarthana Dalal, Plato Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
grade 2
medicine.medical_treatment Clinical Trials and Supportive Activities Clinical Sciences Gamma knife radiosurgery Gamma knife meningioma Radiosurgery Vaccine Related Meningioma 03 medical and health sciences 0302 clinical medicine Clinical Research Overall survival otorhinolaryngologic diseases Medicine Effective treatment Cancer Neurology & Neurosurgery Gamma Knife business.industry radiosurgery medicine.disease Institutional review board stereotactic Brain Disorders nervous system diseases Radiation necrosis surgical procedures operative 030220 oncology & carcinogenesis Neurology (clinical) sense organs business Nuclear medicine 030217 neurology & neurosurgery |
| Zdroj: | Journal of neurological surgery. Part B, Skull base, vol 78, iss 4 |
| Popis: | Purpose This study aims to report long-term clinical outcomes after Gamma Knife radiosurgery (GKRS) for intracranial grade 2 meningiomas. Methods In this Institutional Review Board approved study, we reviewed records of all patients with grade 2 meningiomas treated with GKRS between 1998 and 2014. Results A total of 97 postoperative histopathologically confirmed grade 2 meningiomas in 75 patients were treated and are included in this study. After a mean follow-up of 41 months, 28 meningiomas had local recurrence (29.79%). Median time to local recurrence was 89 months (mean: 69, range: 47–168). The 3- and 5-year actuarial local control (LC) rates were 68.9 and 55.7%, respectively. The 3- and 5-year overall survival rates were 88.6 and 81.1%, respectively. There was a trend toward worse LC with tumors treated with radiation doses ≤ 13 versus > 13 Gy. There was no radiation necrosis or second malignant tumors noted in our series. Conclusion This report, one of the largest GKRS series for grade 2 meningiomas, demonstrates that GKRS is a safe and effective treatment modality for patients with grade 2 meningiomas with durable tumor control and minimal toxicity. Adjuvant GKRS could be considered as a reasonable treatment approach for patients with grade 2 meningiomas. |
| Databáze: | OpenAIRE |
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