Radiation Retinopathy as an Experimental Model for Ischemic Proliferative Retinopathy and Rubeosis Iridis
| Autor: | Irmgard S. Wood, A. Rodman Irvine |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures Radiation retinopathy Iris Neovascularization chemistry.chemical_compound Retinal Diseases Ischemia Animals Cebus Medicine Fluorescein Angiography Retina Rubeosis iridis Neovascularization Pathologic medicine.diagnostic_test business.industry Retinal Vessels Retinal medicine.disease Fluorescein angiography eye diseases Disease Models Animal Radiation Injuries Experimental Ophthalmology medicine.anatomical_structure Iris Diseases chemistry sense organs medicine.symptom business Perfusion Retinopathy |
| Zdroj: | American Journal of Ophthalmology. 103:790-797 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(14)74395-8 |
| Popis: | We produced radiation retinopathy in capuchin monkeys and studied them with fluorescein angiography and light and electron microscopy. The animals were followed up from ten days to 3 1/2 years after radiation in order to determine whether this could provide an experimental model for other chronic ischemic-proliferative retinopathies, such as diabetes. The first change detected after radiation was the focal loss of capillary endothelial cells and pericytes. As the areas of acellular capillaries became confluent, cotton-wool spots became visible ophthalmoscopically. These increased in number and then faded away, leaving large areas of retinal capillary perfusion. Histologic studies showed occlusion first of the deeper, smaller retinal vessels and then gradually of the larger vessels. Intraretinal neovascularization as well as apparent recanalization then developed, but no new vessels extended through the internal limiting lamina into the vitreous. Rubeosis iridis with neovascular glaucoma developed 2 1/2 to 3 1/2 years postirradiation, and vitreous aspirate demonstrated a high level of angiogenic factor. |
| Databáze: | OpenAIRE |
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